脂肪问题:脂质会抗心律失常吗?

Q2 Materials Science Minerals & Metallurgical Processing Pub Date : 2015-12-01 DOI:10.1161/CIRCEP.115.003636
Elaine Wan, Penelope A Boyden
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引用次数: 0

摘要

心脏冠状血管闭塞后,由于血液供应不足,导致肌肉细胞缺氧和葡萄糖缺乏,心脏组织发生缺血和随后的梗死。几分钟内,心电图出现明显改变,提示心肌细胞电障碍,即ST段抬高型心肌梗死(MI)。由于结论后的过程是复杂的,在各种体外研究中,复杂性被分解成不同的方面。解决方案可以模仿缺血和超节奏多细胞和单细胞心脏组织的准备。在这些条件下,人们可以应用电压钳/Ca2+成像来定义在这个急性期发生的特定生化变化如何影响离子通道行为和信号通路。单细胞可以受到缺氧、线粒体氧化链解偶联剂、糖酵解抑制剂、含有高浓度K+和低H+的溶液以及缺乏葡萄糖、两亲体、自由基、儿茶酚胺和拉伸的溶液的影响。carmelie1教授在他1999年的综述中总结了这些数据。这个列表绝不是完整的,并且忽略了某些药物的后果,例如,未减弱的活性氧,由于缺血引起的无氧代谢转变而增强。在再灌注时产生超氧阴离子。活性氧可以从根本上改变蛋白质的结构和功能,其中之一就是由脂质氧化形成活性脂质然而,在大多数研究中,使用的实验组织都来自正常的心脏。Baartscheer等人在本期的研究重点是在急性作用前,膜脂质组成和离子通道功能的变化的影响。
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来源期刊
Minerals & Metallurgical Processing
Minerals & Metallurgical Processing 工程技术-矿业与矿物加工
CiteScore
0.84
自引率
0.00%
发文量
0
审稿时长
>12 weeks
期刊介绍: For over twenty-five years, M&MP has been your source for the newest thinking in the processing of minerals and metals. We cover the latest developments in a wide range of applicable disciplines, from metallurgy to computer science to environmental engineering. Our authors, experts from industry, academia and the government, present state-of-the-art research from around the globe.
期刊最新文献
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