使用地氟醚联合右美托咪定抑制全身麻醉下老年患者术后神经认知障碍的可行性研究:透视研究

Ibrain Pub Date : 2022-11-23 DOI:10.1002/ibra.12073
Yue Hu, Yong Ye, Hui Lin, Jun-Jie Chen, Ting-Ting Sun, Gong-Wei Zhang, Na Wang, Yuan-Hang Shu, Xue Gong, Fei-Fei Ran, Jia-Li Zhang, Yong Tao
{"title":"使用地氟醚联合右美托咪定抑制全身麻醉下老年患者术后神经认知障碍的可行性研究:透视研究","authors":"Yue Hu,&nbsp;Yong Ye,&nbsp;Hui Lin,&nbsp;Jun-Jie Chen,&nbsp;Ting-Ting Sun,&nbsp;Gong-Wei Zhang,&nbsp;Na Wang,&nbsp;Yuan-Hang Shu,&nbsp;Xue Gong,&nbsp;Fei-Fei Ran,&nbsp;Jia-Li Zhang,&nbsp;Yong Tao","doi":"10.1002/ibra.12073","DOIUrl":null,"url":null,"abstract":"<p>This study aimed to explore whether the combined application of desflurane and dexmedetomidine (Dex) reduces the occurrence of postoperative neurocognitive disorders (PND) in patients. We selected patients in our hospital who underwent surgery under general anesthesia, and divided them into two groups: Dex and desflurane (Dex + Des) and desflurane (Des) groups. The data of patients were collected and the Mini-Mental State Examination (MMSE) score was used to assess cognitive status. The blood cell counts were determined preoperatively and on postoperative days 1, 3, and 6, and the percentage of neutrophils and lymphocytes were also recorded. The statistical methods used were the independent-samples <i>t</i>-test and the <i>χ</i><sup>2</sup> test. Pearson's correlation was used to analyze the correlation between PND and inflammation. The incidence of PND in the Dex + Des group was lower than that in the Des group. The postoperative MMSE scores in the Dex + Des group were higher than those in the Des group (<i>p</i> = 0.032). The percentage of neutrophils in the Dex + Des group was significantly lower than that in the Des group on the first and third days after surgery (<i>p</i> = 0.007; <i>p</i> = 0.028). The MMSE scores on the first day after surgery were negatively correlated with the multiple changes in white blood counts and the percentage of neutrophils (<i>r</i> = −0.3038 and −0.3330). Dex combined with Des reduced the incidence of PND and reduced the postoperative inflammatory cell counts.</p>","PeriodicalId":94030,"journal":{"name":"Ibrain","volume":null,"pages":null},"PeriodicalIF":0.0000,"publicationDate":"2022-11-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/ibra.12073","citationCount":"0","resultStr":"{\"title\":\"Feasibility study of use of desflurane combined with dexmedetomidine in inhibiting postoperative neurocognitive disorders in elderly patients under general anesthesia: A perspective study\",\"authors\":\"Yue Hu,&nbsp;Yong Ye,&nbsp;Hui Lin,&nbsp;Jun-Jie Chen,&nbsp;Ting-Ting Sun,&nbsp;Gong-Wei Zhang,&nbsp;Na Wang,&nbsp;Yuan-Hang Shu,&nbsp;Xue Gong,&nbsp;Fei-Fei Ran,&nbsp;Jia-Li Zhang,&nbsp;Yong Tao\",\"doi\":\"10.1002/ibra.12073\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p>This study aimed to explore whether the combined application of desflurane and dexmedetomidine (Dex) reduces the occurrence of postoperative neurocognitive disorders (PND) in patients. We selected patients in our hospital who underwent surgery under general anesthesia, and divided them into two groups: Dex and desflurane (Dex + Des) and desflurane (Des) groups. The data of patients were collected and the Mini-Mental State Examination (MMSE) score was used to assess cognitive status. The blood cell counts were determined preoperatively and on postoperative days 1, 3, and 6, and the percentage of neutrophils and lymphocytes were also recorded. The statistical methods used were the independent-samples <i>t</i>-test and the <i>χ</i><sup>2</sup> test. Pearson's correlation was used to analyze the correlation between PND and inflammation. The incidence of PND in the Dex + Des group was lower than that in the Des group. The postoperative MMSE scores in the Dex + Des group were higher than those in the Des group (<i>p</i> = 0.032). The percentage of neutrophils in the Dex + Des group was significantly lower than that in the Des group on the first and third days after surgery (<i>p</i> = 0.007; <i>p</i> = 0.028). The MMSE scores on the first day after surgery were negatively correlated with the multiple changes in white blood counts and the percentage of neutrophils (<i>r</i> = −0.3038 and −0.3330). Dex combined with Des reduced the incidence of PND and reduced the postoperative inflammatory cell counts.</p>\",\"PeriodicalId\":94030,\"journal\":{\"name\":\"Ibrain\",\"volume\":null,\"pages\":null},\"PeriodicalIF\":0.0000,\"publicationDate\":\"2022-11-23\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://onlinelibrary.wiley.com/doi/epdf/10.1002/ibra.12073\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Ibrain\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://onlinelibrary.wiley.com/doi/10.1002/ibra.12073\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"\",\"JCRName\":\"\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Ibrain","FirstCategoryId":"1085","ListUrlMain":"https://onlinelibrary.wiley.com/doi/10.1002/ibra.12073","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
引用次数: 0

摘要

本研究旨在探讨联合应用地氟醚和右美托咪定(Dex)是否能减少患者术后神经认知障碍(PND)的发生。我们选取了本院在全身麻醉下接受手术的患者,并将其分为两组:德司+地氟醚组(Dex + Des)和地氟醚组(Des)。收集患者的数据,并使用迷你精神状态检查(MMSE)评分来评估认知状况。术前和术后第 1、3 和 6 天测定血细胞计数,并记录中性粒细胞和淋巴细胞的百分比。统计方法采用独立样本 t 检验和 χ2 检验。Pearson 相关性用于分析 PND 与炎症之间的相关性。Dex+Des组的PND发生率低于Des组。Dex + Des组的术后MMSE评分高于Des组(P = 0.032)。术后第一天和第三天,Dex + Des 组的中性粒细胞百分比明显低于 Des 组(p = 0.007;p = 0.028)。术后第一天的 MMSE 评分与白细胞计数和中性粒细胞百分比的多重变化呈负相关(r = -0.3038 和 -0.3330)。Dex 联合 Des 可降低 PND 的发生率,并减少术后炎性细胞计数。
本文章由计算机程序翻译,如有差异,请以英文原文为准。

摘要图片

查看原文
分享 分享
微信好友 朋友圈 QQ好友 复制链接
本刊更多论文
Feasibility study of use of desflurane combined with dexmedetomidine in inhibiting postoperative neurocognitive disorders in elderly patients under general anesthesia: A perspective study

This study aimed to explore whether the combined application of desflurane and dexmedetomidine (Dex) reduces the occurrence of postoperative neurocognitive disorders (PND) in patients. We selected patients in our hospital who underwent surgery under general anesthesia, and divided them into two groups: Dex and desflurane (Dex + Des) and desflurane (Des) groups. The data of patients were collected and the Mini-Mental State Examination (MMSE) score was used to assess cognitive status. The blood cell counts were determined preoperatively and on postoperative days 1, 3, and 6, and the percentage of neutrophils and lymphocytes were also recorded. The statistical methods used were the independent-samples t-test and the χ2 test. Pearson's correlation was used to analyze the correlation between PND and inflammation. The incidence of PND in the Dex + Des group was lower than that in the Des group. The postoperative MMSE scores in the Dex + Des group were higher than those in the Des group (p = 0.032). The percentage of neutrophils in the Dex + Des group was significantly lower than that in the Des group on the first and third days after surgery (p = 0.007; p = 0.028). The MMSE scores on the first day after surgery were negatively correlated with the multiple changes in white blood counts and the percentage of neutrophils (r = −0.3038 and −0.3330). Dex combined with Des reduced the incidence of PND and reduced the postoperative inflammatory cell counts.

求助全文
通过发布文献求助,成功后即可免费获取论文全文。 去求助
来源期刊
CiteScore
0.90
自引率
0.00%
发文量
0
期刊最新文献
Issue Information Identification of immune infiltration and PANoptosis-related molecular clusters and predictive model in Alzheimer's disease based on transcriptome analysis The application of eXplainable artificial intelligence in studying cognition: A scoping review Neuroscience of cancer: Research progress and emerging of the field Calcium accumulation or iron deposition: Delving into the temporal sequence of amyotrophic lateral sclerosis pathophysiology in the primary motor cortex
×
引用
GB/T 7714-2015
复制
MLA
复制
APA
复制
导出至
BibTeX EndNote RefMan NoteFirst NoteExpress
×
×
提示
您的信息不完整,为了账户安全,请先补充。
现在去补充
×
提示
您因"违规操作"
具体请查看互助需知
我知道了
×
提示
现在去查看 取消
×
提示
确定
0
微信
客服QQ
Book学术公众号 扫码关注我们
反馈
×
意见反馈
请填写您的意见或建议
请填写您的手机或邮箱
已复制链接
已复制链接
快去分享给好友吧!
我知道了
×
扫码分享
扫码分享
Book学术官方微信
Book学术文献互助
Book学术文献互助群
群 号:481959085
Book学术
文献互助 智能选刊 最新文献 互助须知 联系我们:info@booksci.cn
Book学术提供免费学术资源搜索服务,方便国内外学者检索中英文文献。致力于提供最便捷和优质的服务体验。
Copyright © 2023 Book学术 All rights reserved.
ghs 京公网安备 11010802042870号 京ICP备2023020795号-1