微生物发现的创新,针对沉默代谢和新的化学多样性

Zeinab G. Khalil
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引用次数: 0

摘要

很明显,微生物(细菌或真菌)粗提取物含有几种重要的生物活性化合物,其中一些已经显示出其治疗活性。遗憾的是,大多数化合物尚未得到适当的评价,用于探索新的铅分子。此外,少数生物活性化合物的一些作用机制迄今尚未确定。因此,需要广泛的研究来发现微生物粗提取物中化合物的活性,并利用它们的治疗潜力来解锁沉默的次级代谢物。因此,这篇综述文章提出了激活微生物次生代谢物的重要性,并指出需要新的工具来获取完整的微生物基因组
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Innovations in Microbial Biodiscovery, Targeting Silent Metabolism and New Chemical Diversity
It is quite evident that microbial (bacteria or fungi) crude extracts contain several important bioactive compounds and some have already shown their therapeutic activity. Unfortunately, most of the compounds have not properly been evaluated for the exploration of new lead molecule. Moreover, some of the mechanisms of actions of few bioactive compounds have not been identified so far. Hence, extensive research is required to find out the activity of compounds in the microbial crude extracts and to exploit their therapeutic potential to unlock silent secondary metabolites. Therefore, this review article raise the importance of activating microbial secondary metabolites noting the need for new tools to access the full microbial genome
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