{"title":"步进过程中驱动蛋白分子扭曲的测定","authors":"Basudev Roy, Avin Ramaiya, E. Schäffer","doi":"10.1364/OMA.2019.AM2E.1","DOIUrl":null,"url":null,"abstract":"Kinesin molecules “walk” on microtubules with 8 nm steps. Typically, it is believed to not twist during the motilty. It is this very aspect that we probe using birefringent microspheres of liquid crystalline material RM257 (Merck) upon placing them under crossed polarizers during motility and also using the Optical Micro-Protractor that uses the optical tweezers and detect the twist and the torque generated by the kinesin molecules during stepping.","PeriodicalId":8973,"journal":{"name":"Biophotonics Congress: Optics in the Life Sciences Congress 2019 (BODA,BRAIN,NTM,OMA,OMP)","volume":"8 1","pages":""},"PeriodicalIF":0.0000,"publicationDate":"2019-04-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Determination of twisting of kinesin molecules during stepping\",\"authors\":\"Basudev Roy, Avin Ramaiya, E. Schäffer\",\"doi\":\"10.1364/OMA.2019.AM2E.1\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"Kinesin molecules “walk” on microtubules with 8 nm steps. Typically, it is believed to not twist during the motilty. It is this very aspect that we probe using birefringent microspheres of liquid crystalline material RM257 (Merck) upon placing them under crossed polarizers during motility and also using the Optical Micro-Protractor that uses the optical tweezers and detect the twist and the torque generated by the kinesin molecules during stepping.\",\"PeriodicalId\":8973,\"journal\":{\"name\":\"Biophotonics Congress: Optics in the Life Sciences Congress 2019 (BODA,BRAIN,NTM,OMA,OMP)\",\"volume\":\"8 1\",\"pages\":\"\"},\"PeriodicalIF\":0.0000,\"publicationDate\":\"2019-04-15\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Biophotonics Congress: Optics in the Life Sciences Congress 2019 (BODA,BRAIN,NTM,OMA,OMP)\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://doi.org/10.1364/OMA.2019.AM2E.1\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"\",\"JCRName\":\"\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Biophotonics Congress: Optics in the Life Sciences Congress 2019 (BODA,BRAIN,NTM,OMA,OMP)","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.1364/OMA.2019.AM2E.1","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
Determination of twisting of kinesin molecules during stepping
Kinesin molecules “walk” on microtubules with 8 nm steps. Typically, it is believed to not twist during the motilty. It is this very aspect that we probe using birefringent microspheres of liquid crystalline material RM257 (Merck) upon placing them under crossed polarizers during motility and also using the Optical Micro-Protractor that uses the optical tweezers and detect the twist and the torque generated by the kinesin molecules during stepping.
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