多发性骨髓瘤患者淀粉样变的口腔表现:1例报告

Q4 Pharmacology, Toxicology and Pharmaceutics Acta Marisiensis - Seria Medica Pub Date : 2023-06-01 DOI:10.2478/amma-2023-0019
Jayachandran Sadaksharam, S. Priya, Sripriya Subramaniam, Archana Muralidharan
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引用次数: 0

摘要

淀粉样变性是指在不同部位形成无定形的、细胞外的、嗜酸性蛋白沉积的一系列疾病。在这篇文章中,我们描述了一例淀粉样变合并多发性骨髓瘤,其中该疾病的口腔症状是主要的诊断线索。一位60岁出头的男性患者,有多处舌头肿胀来到我科。在切口活检后,组织学分析显示存在嗜酸性粒细胞,无定形透明样物质,刚果红染色阳性,表明淀粉样变性。活检后患者骨髓穿刺中出现异常浆细胞提示多发性骨髓瘤。该患者目前正在接受CyBorD(环磷酰胺、硼替佐米和地塞米松)治疗刚刚确诊的多发性骨髓瘤。我们提供这个例子来证明,虽然不常见,淀粉样变性最初只能表现为舌头上的大量肿胀。
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Oral manifestations of amyloidosis in a multiple myeloma patient: A case report
Abstract The term amyloidosis refers to a wide range of diseases in which amorphous, extracellular, eosinophilic proteinaceous deposits form at various locations. In this article, we describe a case of amyloidosis with multiple myeloma in which the oral symptoms of the disease served as the main diagnostic clues. A male patient in his early 60s who had multiple tongue swellings presented to our department. Following an incisional biopsy, histological analysis revealed the presence of eosinophilic, amorphous hyaline-like material that was positive for Congo red staining and was indicative of amyloidosis. The presence of abnormal plasma cells in the patient’s bone marrow aspiration after the biopsy was done was suggestive of multiple myeloma. The patient is currently undergoing the CyBorD (Cyclophosphamide, Bortezomib, and Dexamethasone) treatment for multiple myeloma that has just been diagnosed. We offer this instance to demonstrate that, although uncommon, amyloidosis can initially only manifest as numerous swellings on the tongue.
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来源期刊
Acta Marisiensis - Seria Medica
Acta Marisiensis - Seria Medica Pharmacology, Toxicology and Pharmaceutics-Pharmacology, Toxicology and Pharmaceutics (all)
CiteScore
0.40
自引率
0.00%
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0
审稿时长
24 weeks
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