J. Bégué, D. Bonnet‐Delpon, J. Percy, M. Rock, R. Wilkes
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Facile syntheses of gem-difluoroalkenes from chlorodifluoromethylketones
Chlorodifluoromethyl ketones reacted with diazomethane to afford epoxides in high yield; upon treatment with butyllithium, the epoxides underwent efficient ring opening to afford 3,3-difluoro-2-alkyl-alken-1-ols, suitable substrates for sigmatropic rearrangement leading to compounds containing a CF2 group in mid-chain.
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