Ca2+/CaM 与电压门控 Na+ 通道的相互作用

IF 0.6 Q4 CRIMINOLOGY & PENOLOGY Safer Communities Pub Date : 2019-12-26 Epub Date: 2019-12-03 DOI:10.1073/pnas.1909835116
Geoffrey S Pitt, Seok-Yong Lee
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引用次数: 0

摘要

Gardill等人(1)描述了Ca2+负载钙调蛋白(CaM)和心脏NaV1.5 Na+通道胞内C端(C端结构域[CTD])复合物的晶体结构(Protein Data Bank [PDB]: 6MUD)。他们发现,正如我们报道的(2),NaVCTD, Ca2+-CaM和成纤维细胞生长因子同源因子(FHF) FGF13B(3,4)的三重复合物(PDB: 4JQ0和4JPZ), Ca2+仅占据CaM n -叶,而CaM c -叶采用半开放的构象,当apoCaM结合靶肽时发现(5)。然而,Gardill等人指出,我们已经将我们的结构解释为Ca2+结合到…[③][1]。电子邮件:geoffrey.pitt在}{med.cornell.edu。[1]: # xref-corresp-1-1
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Ca2+/CaM interaction with voltage-gated Na+ channels.
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来源期刊
Safer Communities
Safer Communities CRIMINOLOGY & PENOLOGY-
CiteScore
1.60
自引率
0.00%
发文量
18
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