胰高血糖素样肽- 1受体激动剂exendin - 4可改善Wistar京都大鼠肠易激综合征模型的胃肠功能障碍

Neurogastroenterology & Motility Pub Date : 2019-10-11 DOI:10.1111/nmo.13738

Rebecca O’Brien, D. O’Malley

{"title":"胰高血糖素样肽- 1受体激动剂exendin - 4可改善Wistar京都大鼠肠易激综合征模型的胃肠功能障碍","authors":"Rebecca O’Brien, D. O’Malley","doi":"10.1111/nmo.13738","DOIUrl":null,"url":null,"abstract":"Glucagon‐like peptide‐1 (GLP‐1) is beneficial in relieving pain‐related symptoms of Irritable bowel syndrome (IBS), a prevalent, multi‐factorial functional bowel disorder characterized by diarrhea and/or constipation, abdominal bloating, and pain. Activation of myenteric neurons has been implicated in the inhibitory effects of GLP‐1 on gastrointestinal motility; however, the mechanisms of action underlying this are not clear.","PeriodicalId":19104,"journal":{"name":"Neurogastroenterology & Motility","volume":"13 1","pages":""},"PeriodicalIF":0.0000,"publicationDate":"2019-10-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"11","resultStr":"{\"title\":\"The Glucagon‐like peptide‐1 receptor agonist, exendin‐4, ameliorated gastrointestinal dysfunction in the Wistar Kyoto rat model of Irritable Bowel Syndrome\",\"authors\":\"Rebecca O’Brien, D. O’Malley\",\"doi\":\"10.1111/nmo.13738\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"Glucagon‐like peptide‐1 (GLP‐1) is beneficial in relieving pain‐related symptoms of Irritable bowel syndrome (IBS), a prevalent, multi‐factorial functional bowel disorder characterized by diarrhea and/or constipation, abdominal bloating, and pain. Activation of myenteric neurons has been implicated in the inhibitory effects of GLP‐1 on gastrointestinal motility; however, the mechanisms of action underlying this are not clear.\",\"PeriodicalId\":19104,\"journal\":{\"name\":\"Neurogastroenterology & Motility\",\"volume\":\"13 1\",\"pages\":\"\"},\"PeriodicalIF\":0.0000,\"publicationDate\":\"2019-10-11\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"11\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Neurogastroenterology & Motility\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://doi.org/10.1111/nmo.13738\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"\",\"JCRName\":\"\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Neurogastroenterology & Motility","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.1111/nmo.13738","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}

引用次数: 11

摘要

胰高血糖素样肽- 1 (GLP - 1)有助于缓解肠易激综合征(IBS)的疼痛相关症状，IBS是一种常见的多因素功能性肠紊乱，以腹泻和/或便秘、腹胀和疼痛为特征。肌肠神经元的激活与GLP‐1对胃肠运动的抑制作用有关;然而，其作用机制尚不清楚。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

查看原文

微信好友朋友圈 QQ好友复制链接

本刊更多论文

The Glucagon‐like peptide‐1 receptor agonist, exendin‐4, ameliorated gastrointestinal dysfunction in the Wistar Kyoto rat model of Irritable Bowel Syndrome

Glucagon‐like peptide‐1 (GLP‐1) is beneficial in relieving pain‐related symptoms of Irritable bowel syndrome (IBS), a prevalent, multi‐factorial functional bowel disorder characterized by diarrhea and/or constipation, abdominal bloating, and pain. Activation of myenteric neurons has been implicated in the inhibitory effects of GLP‐1 on gastrointestinal motility; however, the mechanisms of action underlying this are not clear.

求助全文

通过发布文献求助，成功后即可免费获取论文全文。去求助

来源期刊

Neurogastroenterology & Motility

自引率

0.00%

发文量