Synthesis and Biological Activity of Triazole Analogues of Piperazine

A new series of novel (5-methyl-1-phenyl-1H-1,2,3-triazol-4-yl)(4arylpiperazino)methanone 8(a-j) has been synthesized from 5-methyl-1-phenyl-1H1,2,3-triazole-4-carboxylic acid 4 and 1-arylpiperazine 7(a-j). Chemical structures of all the new compounds were established by IR, H, C NMR and MS data. The compounds 8(a-j) were evaluated for their antibacterial activity against four human pathogenic bacteria viz., Escherichia coli, Klebseilla pneumoniae, Shigella dysentriae and Shigella flexnei. Amongst them, compounds having 4-methylphenyl 8b, 4-methoxyphenyl 8c, 4-fluorophenyl 8d, 4-bromophenyl 8e and 3-nitrophenyl 8f moieties on piperazine ring showed significant inhibition of bacterial growth and emerged as potential molecules for further development.