SARS-CoV - 2感染骨关节炎患者血浆抗氧化保护系统指标的研究

Yu. Tugarev, Kateryna Dvorshchenko
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引用次数: 0

摘要

2019年12月在中国武汉爆发的肺炎疫情导致了与严重急性呼吸综合征相关的冠状病毒2 (SARS-CoV-2)的传播。2020年1月30日,中国新冠肺炎确诊病例不断增加,世界卫生组织宣布新冠肺炎疫情为突发公共卫生事件。2019冠状病毒病(2019冠状病毒病,COVID-19)对世界上许多国家人民的健康造成了毁灭性影响。众所周知,SARS-CoV-2病毒除了损害肺实质外,还可损害其他器官系统,并使合并症患者(特别是骨关节炎患者)的病情复杂化。氧化应激在骨关节炎的形成和发展中起着重要作用。它的发展与氧化-抗氧化平衡的破坏有关。本研究旨在测定SARS-CoV-2感染后OA患者血浆中抗氧化系统的指标。所有研究参与者进一步分为三个实验组:I组-条件健康人,II组-II -III度膝关节OA患者,III组- 6-9个月前患有轻度或中重度COVID-19的II-III度膝关节OA患者。超氧化物歧化酶和过氧化氢酶活性及巯基含量采用通用的生化方法测定。使用普遍接受的变分统计方法对研究结果进行处理。结果发现,感染COVID-19的骨关节炎患者血浆中抗自由基酶(超氧化物歧化酶和过氧化氢酶)的活性和含有sh基团(蛋白质和非蛋白质性质)的化合物的含量降低。所得结果表明,氧化-抗氧化平衡向促氧化方向转变。与没有感染冠状病毒的骨关节炎患者相比,这些疾病更为严重。我们的研究结果表明,感染COVID-19后,骨关节炎患者可能会经历更严重的骨关节炎病程并出现并发症。
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INDICATORS OF THE ANTIOXIDANT PROTECTION SYSTEM IN THE BLOOD PLASMA OF PATIENTS WITH OSTEOARTHRITIS AFTER SARS-CoV 2-INFECTION
An outbreak of pneumonia that began in December 2019 in Wuhan (China) caused the spread of severe acute respiratory syndrome-related coronavirus 2 (SARS-CoV-2). After an increase in the number of positive cases of infection in China, on January 30, 2020, the World Health Organization declared the virus epidemic a public health emergency. The 2019 coronavirus disease (Coronavirus disease 2019, COVID-19) has a devastating effect on the health of people in many countries around the world. It is known that the SARS-CoV-2 virus, in addition to damaging the lung parenchyma, can damage other organ systems and complicate the condition of patients with comorbid diseases, in particular, with osteoarthritis. Oxidative stress plays an important role in the formation and progression of osteoarthritis. Its development is associated with a violation of the oxidative-antioxidant balance. The aim of the work was to determine the indicators of the antioxidant system in the blood plasma of patients with OA after SARS-CoV-2 infection. All study participants were further divided into three experimental groups: Group I – conditionally healthy people, Group II – patients with OA of the knee joints of the II-III degree, and Group III – patients with OA of the knee joints of the II–III degree who suffered a mild or moderately severe form COVID-19 6–9 months ago. Superoxide dismutase and catalase activity and the content of sulfhydryl groups were determined by generally accepted biochemical methods. Processing of research results was carried out using generally accepted methods of variational statistics. It was found that the activity of anti-radical enzymes (superoxide dismutase and catalase) and the content of compounds containing SH-groups (of protein and non-protein nature) are reduced in the blood plasma of osteoarthritis patients who contracted COVID-19. The obtained results indicate a shift of the oxidant-antioxidant balance in the pro-oxidant direction. These disorders are more profound compared to patients with osteoarthritis who did not suffer from coronavirus infection. The results obtained by us indicate that patients with osteoarthritis may experience a more severe course of osteoarthritis and develop complications after infection with COVID-19.
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