烷基苯磺酸钠和镍对豚鼠皮肤的毒性

Journal of Toxicology-cutaneous and Ocular Toxicology Pub Date : 2001-01-01 DOI:10.1081/CUS-100000337

A. Mathur, R. Shanker

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引用次数: 3

摘要

豚鼠皮肤暴露于线性烷基苯磺酸盐(LAS)或镍或两者的组合。总的来说，脂质过氧化、组胺含量、酸性磷酸酶、β-葡萄糖醛酸酶、碱性磷酸酶和谷胱甘肽- s转移酶在同时暴露于LAS和Ni时均升高。皮肤中镍含量也有所增加。组织学上，当皮肤同时暴露于LAS和Ni时，皮肤显示更多的角化过度和退行性变化。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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DERMAL TOXICITY OF LINEAR ALKYLBENZENE SULPHONATE AND NICKEL IN GUINEA PIGS

Guinea pigs were dermally exposed to linear alkylbenzene sulphonate (LAS) or nickel or in combination. In general, lipid peroxidation, histamine contents, acid phosphatase, β-glucuronidase, alkaline phosphatase, and glutathione-S-transferase showed elevations when exposed simultaneously to LAS and Ni. The Ni contents also increased in the skin. Histologically the skin revealed more hyperkeratinization and degenerative changes when it was exposed simultaneously to LAS and Ni.

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Journal of Toxicology-cutaneous and Ocular Toxicology

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