怀疑阻塞性睡眠呼吸暂停的受试者呼出一氧化氮的研究:越南的一项试点研究

IF 2 Q3 RESPIRATORY SYSTEM Pulmonary Medicine Pub Date : 2016-01-13 DOI:10.1155/2016/3050918
S. Duong-Quy, T. Hua-Huy, Huyen-Tran Tran-Mai-Thi, N. Le-Dong, T. Craig, A. Dinh-Xuan
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引用次数: 23

摘要

背景和目的。阻塞性睡眠呼吸暂停(OSA)患者呼出的一氧化氮(eNO)浓度升高,反映气道上皮诱导型一氧化氮合酶的活性。本研究旨在测量疑似OSA患者的eNO浓度,并将不同eNO参数与临床和睡眠呼吸暂停特征联系起来。方法。在这项横断研究中,所有患者都在实验室进行了夜间多导睡眠图(PSG)和eNO测量,采用多导睡眠图前后(PSG前和PSG后)的多流速方法。结果。根据PSG结果将82例患者分为两组:对照组(n = 30);54±14岁)和呼吸暂停低通气指数(AHI)≥5/小时的OSA患者(n = 52;53±12岁)。OSA患者的身体质量指数(BMI)、颈腹围均明显高于对照组。OSA组psg后肺泡NO浓度(CANO)(5.3±1.9 ppb)显著高于psg前CANO(4.0±1.7 ppb);P < 0.001)。CANO与AHI呈显著相关(P < 0.001), CANO与最低点SpO2呈显著相关(P < 0.05)。白天CANO值大于4.1 ppb可用于筛查有症状的受试者是否存在OSA,特异性高,为93.3%。结论。我们的研究结果表明,CANO在有提示症状的患者中可作为OSA的替代标志物。
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Study of Exhaled Nitric Oxide in Subjects with Suspected Obstructive Sleep Apnea: A Pilot Study in Vietnam
Background and Objective. The concentration of exhaled nitric oxide (eNO), reflecting the activity of inducible NO synthase in airway epithelium, has been found to increase in patients with obstructive sleep apnea (OSA). This study aimed to measure eNO concentration in patients with suspected OSA and to correlate different eNO parameters with clinical and sleep apnea characteristics. Methods. In this cross-sectional study, all patients underwent in-lab overnight polysomnography (PSG) and eNO measurement using a method of multiple flow rates before and after PSG (pre- and post-PSG). Results. According to the result of PSG, 82 persons were divided into two groups: control subjects (n = 30; 54 ± 14 years) and patients with OSA defined as apnea-hypopnea index (AHI) ≥ 5/hour (n = 52; 53 ± 12 years). Body mass index (BMI) and neck and abdomen circumferences of OSA patients were significantly higher than those from control subjects. In OSA group, post-PSG alveolar NO concentration (CANO) (5.3 ± 1.9 ppb) was significantly higher than pre-PSG CANO (4.0 ± 1.7 ppb; P < 0.001). Significant correlations have been found between CANO and AHI (P < 0.001) and between CANO and nadir SpO2 (P < 0.05). The daytime CANO value of more than 4.1 ppb can be used to screen symptomatic subjects for the presence of OSA with a high specificity of 93.3%. Conclusion. Our findings indicate CANO as a surrogate marker for OSA in persons with suggestive symptoms.
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来源期刊
Pulmonary Medicine
Pulmonary Medicine RESPIRATORY SYSTEM-
CiteScore
10.20
自引率
0.00%
发文量
4
审稿时长
14 weeks
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