丁丙诺啡治疗阿片类药物依赖:制剂之间真的有区别吗?

Rebecca L. Graham
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引用次数: 1

摘要

丁丙诺啡和丁丙诺啡/纳洛酮舌下片于2002年获得FDA批准。2010年,丁丙诺啡/纳洛酮舌下膜获得批准,以解决片剂转移、片剂溶解时间和片剂儿童意外暴露的问题。本文将比较丁丙诺啡舌下制剂的药代动力学、安全性、转移和误用、成本和患者偏好。它将探讨目前的数据,表明各种配方的优点或缺点,因为结论性数据是最低限度的。
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Buprenorphine for opioid dependence: Are there really differences between the formulations?
Buprenorphine and buprenorphine/naloxone sublingual tablets were approved by the FDA in 2002. In 2010, the buprenorphine/naloxone sublingual film was approved to address concerns of diversion, time for tablet dissolution, and unintentional exposure in children with the tablet. This article will compare the buprenorphine sublingual formulations in terms of pharmacokinetics, safety, diversion and misuse, cost, and patient preference. It will explore current data suggesting advantages or disadvantages of the various formulations since conclusive data are minimally available.
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