绝经后妇女的宫颈绒毛膜癌:病例报告和文献复习

IF 0.1 Q4 OBSTETRICS & GYNECOLOGY Journal of Clinical Obstetrics and Gynecology Pub Date : 2022-01-31 DOI:10.29328/journal.cjog.1001101
Nazari Zeinab, Mortazavi Leila, Gordani Noushin
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引用次数: 1

摘要

背景:宫颈绒毛膜癌是一种由多能性腺生殖细胞引起的恶性滋养细胞肿瘤。预计会出现多种表现,包括阴道出血和与转移有关的症状。在此,我们报告一例原发性绒毛膜癌在绝经后的妇女。病例介绍:一名67岁女性,表现为阴道出血和下腹部疼痛。除了β-hCG滴度为14850 IU/L外,超声和实验室检查结果均正常。宫腔镜检查发现子宫颈后壁有息肉。因怀疑绒毛膜癌行子宫切除及双侧输卵管卵巢切除术。术后β-hCG滴度立即下降。然而,术后1个月β-hCG滴度再次升高,并继续每周给予甲氨蝶呤治疗。结论:阴道出血是绝经后妇女重要的临床表现。虽然这些患者的绒毛膜癌治疗尚无具体的指南,但基于治疗反应和β-hCG滴定的化疗后子宫切除术是有利的。
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Cervical choriocarcinoma in a post-menopause woman: Case report and review of literature
Background: Cervical choriocarcinoma is a malignant trophoblastic neoplasm that arises from pluripotent gonadal germ cells. Various manifestations are expected including vaginal bleeding and symptoms related to metastasis. Here, we report a case of primary choriocarcinoma in a post-menopausal woman. Case presentation: A 67-year-old woman presented with vaginal bleeding and lower abdominal pain. Ultrasound and laboratory results were normal except for a β-hCG titer of 14850 IU/L. Hysteroscopy revealed a polyp in the posterior wall of the cervix. hysterectomy and bilateral salpingo-oophorectomy were performed due to suspected choriocarcinoma. The β-hCG titer decreased immediately after surgery. However, the β-hCG titer increased again one month after surgery and treatment was continued with weekly methotrexate administration. Conclusion: Manifestations such as vaginal bleeding is very important in post-menopausal women. Although there are no specific guidelines for the treatment of choriocarcinoma in these patients, hysterectomy following chemotherapy based on response to treatment and β-hCG titration is favorable.
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来源期刊
Journal of Clinical Obstetrics and Gynecology
Journal of Clinical Obstetrics and Gynecology Medicine-Obstetrics and Gynecology
CiteScore
0.30
自引率
0.00%
发文量
8
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