COVID-19大流行对抗逆转录病毒治疗依从性的影响

A. Fernandes, A. Brito, T. Mendes, A. Alcobia
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引用次数: 3

摘要

背景和重要性在2019冠状病毒病大流行的背景下,许多患者甚至为了获得抗逆转录病毒治疗(ART)等基本药物也避免搬离家园。高依从性(95%以上)对于获得病毒抑制至关重要,并与降低死亡率和发病率相关。抗逆转录病毒治疗依从性差是HIV患者和HIV耐药菌株治疗失败的首要原因目的和目的评价和表征COVID-19大流行对抗逆转录病毒治疗依从性的影响,并确定大流行期间影响依从性的主要因素材料和方法在2019年和2020年第一学期进行回顾性、横向、比较研究,纳入接受抗逆转录病毒治疗的HIV患者。为了衡量依从性,分析了配药记录,注册变量是性别、可能影响依从性的风险因素和药片编号,数据来自电子病历,用于统计分析,配对t测试是用来确定如果有病人依从性的差异之前和之后COVID-19流行Results100患者在研究期间进行分析,平均年龄为48 9±12 3年2019年的67%和61%是男性艺术依从性(67%男性non-adherent)而在2020年这个数据是43%(58%男性non-adherent)比较两年,有一个依从率减少24%,这是显著(p = 0 006)减少的主要原因是:结论和相关性研究结果表明,COVID-19大流行影响了艾滋病毒患者的依从性,所有为确保治疗连续性所做的努力(在社区和医院药房提供药物),重要的是药剂师继续促进治疗依从性和关于COVID-19的教育。该研究的主要局限性是使用的样本减少。监测接受抗逆转录病毒治疗的患者以确保其依从性并了解COVID-19大流行如何以及为什么影响他们的治疗非常重要。需要进一步研究以了解COVID-19大流行对艾滋病毒患者健康的真正影响利益冲突无利益冲突
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4CPS-392 Effect of COVID-19 pandemic on antiretroviral therapy adherence
Background and importanceIn the context of the COVID-19 pandemic, many patients avoided moving from their homes, even to acquire essential drugs, such as antiretroviral therapy (ART) High adherence (more than 95%) is essential to acquire viral suppression and is associated with reduced mortality and morbidity Furthermore, poor ART adherence is the first cause of therapeutic failure in HIV patients and HIV drug resistant strains Aim and objectivesTo evaluate and characterise the effect of the COVID-19 pandemic on adherence to ART and identify the main factors that influenced adherence during the pandemic Material and methodsA retrospective, transversal, comparative study was conducted over the first semester of 2019 and 2020 HIV patients receiving ART were included Exclusion criteria were: deaths, initiated ART during or after the first semester in 2019 and transfer to another hospital To measure adherence, dispensing records were analysed Registered variables were sex, risk factors that could compromise adherence and pill numbers Data were obtained from the electronic medical records For the statistical analysis, the paired t test was used to determine if there were differences in patient adherence before and after the COVID-19 pandemic Results100 patients were analysed during the study period, with an average age of 48 9±12 3 years and 61% were men ART adherence was 67% in 2019 (67% male non-adherent) whereas in 2020 it was 43% (58% male non-adherent) Comparing both years, there was a decrease of 24% in the adherence rate, which was significant (p=0 006) The main reasons for this reduction were: rescheduling of doctor appointments or blood tests, mandatory confinement due to COVID-19 or fear of using the hospital facilities Conclusion and relevanceThe study results suggested that the COVID-19 pandemic affected HIV patient adherence All efforts made to ensure continuity of treatment (medication delivery in the community and hospital pharmacies, teleconsultation) were not enough It is important that pharmacists continue to promote therapeutic adherence and education about COVID-19 The main limitation of the study was the reduced sample used It is highly important to monitor patients with ART to ensure their adherence rate and to understand how and why the COVID-19 pandemic affected their treatment Further research is needed to know the real impact of the COVID-19 pandemic on the health of HIV patients References and/or acknowledgementsConflict of interestNo conflict of interest
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