对羟基苯甲酸和山奈酚的研究

Elvira Hermawati, Suzanny Dwi Ellita, L. D. Juliawaty, E. Hakim
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引用次数: 1

摘要

三魁藤(豆科)广泛分布于印度尼西亚,用作利尿、痔疮、滋补和抗炎的草药。对羟基苯甲酸(1)和山奈酚(2)这两个已知的化合物从三毛藤(Desmodium triquetrum)叶的甲醇提取物中分离得到。根据氢、碳核磁共振数据确定了分离化合物的结构。化合物(1)和(2)对小鼠细胞白血病P-388具有较弱的细胞毒性,IC50分别为55,0和24,7 μg/mL。化合物(1)为该属首次报道。
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p-Hydroxybenzoic Acid and Kaempferol from Desmodium triquetrum
Desmodium triquetrum (Fabaceae) is widely distributed in Indonesia and used as herbal medicines for diuretic, hemorrhoids, tonics, and anti-inflammatory. Two known compounds, p-hydroxybenzoic acid (1) and kaempferol (2), were isolated from the MeOH extract of the leaves of Desmodium triquetrum. The structures of isolated compounds were determined based on H and C NMR data. The MeOH extract showed very active with 6,5 μg/mL in addition, compound (1) and (2) showed weak cytotoxicity against murine cell leukemia P-388 with IC50 55,0 and 24,7 μg/mL, respectively. Compound (1) was the first reported in this species.
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