多糖基气凝胶的生物医学应用综述

Ajish K R, Sreelakshmi K Warrier, Shilpa Sarah Mathew, L. A. Pothan
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摘要

近年来,气凝胶因其在不同领域的迷人能力而成为广泛研究的材料。高孔隙率、大表面积、低导热率、低密度使其在医药、环境工程、食品包装等领域具有重要意义。生物基气凝胶,特别是多糖类气凝胶,除了上述特性外,还具有生物可降解性、低毒性和生物相容性,这使它们比传统的无机气凝胶具有巨大的优势。由淀粉、纤维素、果胶、海藻酸盐、壳聚糖、卡拉胶和琼脂糖前体合成的多糖基气凝胶使生物医学、化妆品、电子、建筑和食品工业的可持续发展成为可能。本文综述了多糖基气凝胶在生物医学上的应用,重点介绍了其在药物输送、组织工程、医用可移植性装置、伤口敷料、生物传感器和生物成像等方面的应用。这些智能材料的未来前景也受到了讨论。
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Biomedical Applications of Polysaccharide-Based Aerogels: A Review
Aerogels, in recent times, have become materials of extensive research due to their fascinating capabilities in different fields. High porosity, large surface area, low thermal conductivity and low density make them significant in fields such as medicine, environmental engineering, food packaging, and so on. Biodegradability, low toxicity and biocompatibility, in addition to the aforementioned properties, offered by bio-based aerogels, especially polysaccharide based aerogels, give them a huge advantage over conventional inorganic ones. Polysaccharide based aerogels synthesised from starch, cellulose, pectin, alginate, chitosan, carrageenan and agarose precursors enable sustainable developments in the biomedical, cosmetic, electronic, construction and food industries. This review focuses on the biomedical applications of polysaccharide based aerogels, with special emphasis on its implications in drug delivery, tissue engineering, medical implantable devices, wound dressing, biosensors and bio-imaging. The future perspectives of these smart materials have also been subjected to discussion.
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