右肾移植患者肺部诺卡菌病1例报告

Anirban Ray, Sushmita Roy Choudhury, S. Unnithan, Angshuman Mukherjee, P. Mondal
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摘要

诺卡菌病是由诺卡菌属细菌感染引起的,诺卡菌属细菌是腐生需氧放线菌,通常存在于土壤中,在标准生化试验中无活性。肺和全身诺卡菌病常见于成年男性,几乎都是散发的,常见于结核病流行地区,通常见于细胞介导免疫缺陷的个体。它可能表现为肺炎、脓肿、心包炎、纵隔炎、喉炎、腹膜炎和脑膜炎。诊断为痰或脓液分枝珠状革兰氏阳性细丝,宽1微米,长50微米。男性免疫功能低下患者出现呼吸道症状。患者在其他地方进行评估并接受多个疗程的抗生素治疗。入院时,我们进行了HRCT胸部检查,随后进行了纤维支气管镜检查。支气管肺泡灌洗液送去做微生物分析。金氏抗酸法和Ziehl - Neelsen染色法检测诺卡菌阳性,采用甲氧苄氨嘧啶-磺胺甲恶唑治疗。
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Case report of pulmonary nocardiosis in a patient of right renal transplantation
Nocardiosis results from infection with bacteria of genus Nocardia, which are saprophytic aerobic actinomycetes that commonly reside in soil relatively and are inactive on standard biochemical tests. Pulmonary and systemic nocardiosis is common in adult males, almost all being sporadic, common in tuberculosis endemic regions and usually seen in individuals with deficient cell mediated immunity. It may present as pneumonia, empyema, pericarditis, mediastinitis, laryngitis, peritonitis, and meningitis. Diagnosed with sputum or pus for branching beaded gram positive filaments which are 1 micron meter wide and 50 micron meter long.A male immunocompromised patient presented with respiratory symptoms. Patient was evaluated elsewhere and received multiple courses of antibiotics. On admission in our facility HRCT thorax followed by fibre optic bronchoscopy was done. Bronchoalveolar lavage was sent for microbiological analysis.  Acid-fast in kinyoun and Ziehl Neelsen stain came positive for Nocardia and was managed with trimethoprim- sulfamethoxazole which is the treatment of choice.
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