胃肠道间质瘤患者日粮给予异核桃脂醇二糖苷的抗癌作用:1例报告

Hao Wu, Yao Wang, Jiarong Chen, Li-ping Wang, Guihai Liu, Shu-Lin Liu
{"title":"胃肠道间质瘤患者日粮给予异核桃脂醇二糖苷的抗癌作用:1例报告","authors":"Hao Wu, Yao Wang, Jiarong Chen, Li-ping Wang, Guihai Liu, Shu-Lin Liu","doi":"10.1097/IJ9.0000000000000103","DOIUrl":null,"url":null,"abstract":"Introduction: Gastrointestinal stromal tumor (GIST) is among the leading malignancies of the digestive system. GIST is not susceptible to chemotherapies and is prone to recurrence or metastasis after surgical operation. Secoisolariciresinol diglucoside (SDG) was suggested to have potential anticancer effects, but no clinical evidence had been available. Here we report successful treatment of a postoperative GIST case with dietary SDG. Presentation of Case: The patient was a 58-year-old man. He had GIST and received resection of small intestinal lesions 1 year before. He was diagnosed with postoperation of GIST and presented with high level of serum carbohydrate antigen 72-4 (CA72-4). The patient was then treated with dietary administration of SDG with his voluntary acceptance for 5 months, and underwent 2 serum CA72-4 measurements during this period. CA72-4 level of the patient was restored to normal range after treatment with dietary SDG for 1 month. There was no aberrant CA72-4 level, recurrence or metastasis after the treatment with dietary SDG. Discussion: This is to our knowledge the fi rst report on application of dietary SDG on a postoperative GIST patient with aberrant level of serum CA72-4. SDG can be transformed into active substances with antitumor effects by human gut bacteria. Dietary SDG might inhibit tumorigenicity and malignant behavior of GIST cells. Conclusion: The excellent effects suggest dietary SDG to be a potential therapy for GIST, especially against recurrence or metastasis. Metastasis, Case","PeriodicalId":42930,"journal":{"name":"International Journal of Surgery-Oncology","volume":"79 1","pages":""},"PeriodicalIF":0.3000,"publicationDate":"2021-01-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"2","resultStr":"{\"title\":\"Anticancer effects of dietary administration of secoisolariciresinol\\n diglucoside in a patient of gastrointestinal stromal tumor: a case\\n report\",\"authors\":\"Hao Wu, Yao Wang, Jiarong Chen, Li-ping Wang, Guihai Liu, Shu-Lin Liu\",\"doi\":\"10.1097/IJ9.0000000000000103\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"Introduction: Gastrointestinal stromal tumor (GIST) is among the leading malignancies of the digestive system. GIST is not susceptible to chemotherapies and is prone to recurrence or metastasis after surgical operation. Secoisolariciresinol diglucoside (SDG) was suggested to have potential anticancer effects, but no clinical evidence had been available. Here we report successful treatment of a postoperative GIST case with dietary SDG. Presentation of Case: The patient was a 58-year-old man. He had GIST and received resection of small intestinal lesions 1 year before. He was diagnosed with postoperation of GIST and presented with high level of serum carbohydrate antigen 72-4 (CA72-4). The patient was then treated with dietary administration of SDG with his voluntary acceptance for 5 months, and underwent 2 serum CA72-4 measurements during this period. CA72-4 level of the patient was restored to normal range after treatment with dietary SDG for 1 month. There was no aberrant CA72-4 level, recurrence or metastasis after the treatment with dietary SDG. Discussion: This is to our knowledge the fi rst report on application of dietary SDG on a postoperative GIST patient with aberrant level of serum CA72-4. SDG can be transformed into active substances with antitumor effects by human gut bacteria. Dietary SDG might inhibit tumorigenicity and malignant behavior of GIST cells. Conclusion: The excellent effects suggest dietary SDG to be a potential therapy for GIST, especially against recurrence or metastasis. Metastasis, Case\",\"PeriodicalId\":42930,\"journal\":{\"name\":\"International Journal of Surgery-Oncology\",\"volume\":\"79 1\",\"pages\":\"\"},\"PeriodicalIF\":0.3000,\"publicationDate\":\"2021-01-20\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"2\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"International Journal of Surgery-Oncology\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://doi.org/10.1097/IJ9.0000000000000103\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q4\",\"JCRName\":\"ONCOLOGY\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"International Journal of Surgery-Oncology","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.1097/IJ9.0000000000000103","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q4","JCRName":"ONCOLOGY","Score":null,"Total":0}
引用次数: 2

摘要

胃肠道间质瘤(GIST)是消化系统的主要恶性肿瘤之一。GIST对化疗不敏感,术后易复发或转移。二异松脂醇二糖苷(SDG)被认为具有潜在的抗癌作用,但尚无临床证据。在这里,我们报告成功的治疗胃肠道间质瘤术后病例饮食SDG。病例表现:患者男,58岁。1年前接受胃肠道间质瘤切除术。术后诊断为GIST,血清碳水化合物抗原72-4 (CA72-4)水平高。在患者自愿接受的情况下,通过膳食给药SDG治疗5个月,并在此期间进行2次血清CA72-4测定。经膳食SDG治疗1个月后,患者CA72-4水平恢复正常。饮食性SDG治疗后未见CA72-4水平异常、复发或转移。讨论:据我们所知,这是首例应用膳食SDG治疗血清CA72-4水平异常的GIST术后患者的报道。SDG可通过人体肠道细菌转化为具有抗肿瘤作用的活性物质。膳食中添加SDG可能抑制GIST细胞的致瘤性和恶性行为。结论:食疗SDG具有良好的疗效,是治疗GIST的潜在治疗方法,特别是治疗复发或转移。转移、案例
本文章由计算机程序翻译,如有差异,请以英文原文为准。
查看原文
分享 分享
微信好友 朋友圈 QQ好友 复制链接
本刊更多论文
Anticancer effects of dietary administration of secoisolariciresinol diglucoside in a patient of gastrointestinal stromal tumor: a case report
Introduction: Gastrointestinal stromal tumor (GIST) is among the leading malignancies of the digestive system. GIST is not susceptible to chemotherapies and is prone to recurrence or metastasis after surgical operation. Secoisolariciresinol diglucoside (SDG) was suggested to have potential anticancer effects, but no clinical evidence had been available. Here we report successful treatment of a postoperative GIST case with dietary SDG. Presentation of Case: The patient was a 58-year-old man. He had GIST and received resection of small intestinal lesions 1 year before. He was diagnosed with postoperation of GIST and presented with high level of serum carbohydrate antigen 72-4 (CA72-4). The patient was then treated with dietary administration of SDG with his voluntary acceptance for 5 months, and underwent 2 serum CA72-4 measurements during this period. CA72-4 level of the patient was restored to normal range after treatment with dietary SDG for 1 month. There was no aberrant CA72-4 level, recurrence or metastasis after the treatment with dietary SDG. Discussion: This is to our knowledge the fi rst report on application of dietary SDG on a postoperative GIST patient with aberrant level of serum CA72-4. SDG can be transformed into active substances with antitumor effects by human gut bacteria. Dietary SDG might inhibit tumorigenicity and malignant behavior of GIST cells. Conclusion: The excellent effects suggest dietary SDG to be a potential therapy for GIST, especially against recurrence or metastasis. Metastasis, Case
求助全文
通过发布文献求助,成功后即可免费获取论文全文。 去求助
来源期刊
自引率
0.00%
发文量
8
期刊最新文献
Retifanlimab: a breakthrough for the management of Merkel cell carcinoma Outcomes of the distal rectal cancer treatment depending on the type of sphincter-sparing surgery Mucinous adenocarcinoma of the urachus: a practical overview of a broad differential diagnosis: case report Spatial and temporal epidemiological analysis on the mortality rate of female breast cancer in Suzhou, China: 2006–2020 Role of Denosumab in the Management of Giant Cell Tumor, a Cross Sectional Study
×
引用
GB/T 7714-2015
复制
MLA
复制
APA
复制
导出至
BibTeX EndNote RefMan NoteFirst NoteExpress
×
×
提示
您的信息不完整,为了账户安全,请先补充。
现在去补充
×
提示
您因"违规操作"
具体请查看互助需知
我知道了
×
提示
现在去查看 取消
×
提示
确定
0
微信
客服QQ
Book学术公众号 扫码关注我们
反馈
×
意见反馈
请填写您的意见或建议
请填写您的手机或邮箱
已复制链接
已复制链接
快去分享给好友吧!
我知道了
×
扫码分享
扫码分享
Book学术官方微信
Book学术文献互助
Book学术文献互助群
群 号:481959085
Book学术
文献互助 智能选刊 最新文献 互助须知 联系我们:info@booksci.cn
Book学术提供免费学术资源搜索服务,方便国内外学者检索中英文文献。致力于提供最便捷和优质的服务体验。
Copyright © 2023 Book学术 All rights reserved.
ghs 京公网安备 11010802042870号 京ICP备2023020795号-1