伊朗人群中网膜基因rs2274907多态性与2型糖尿病的关系

Arezoo Nazari, M. Mohammadi, Masoumeh Nezhadali Lamfjani, T. Naji
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摘要

背景:糖尿病是世界上最常见的慢性代谢性疾病之一,是由胰岛素分泌减少或胰岛素抵抗和内脏脂肪组织(IR)脂肪堆积引起的。网膜是一种从脂肪组织中推断出来的蛋白质,它与糖尿病的发病率有关。本研究旨在探讨amentine-1基因rs2274907多态性与糖尿病的关系。材料与方法:本研究以70例糖尿病患者和70例健康人为对照。测定受试者的FBS、TG、CHOL、HDL和LDL,并采用PCR-RFLP测定基因型。结果:患者年龄、体重指数、LDL、胆固醇、甘油三酯、空腹高糖、胰岛素抵抗与健康组比较差异有统计学意义(p0.05)。不同基因型rs2274907的Omentin水平在健康受试者中存在差异,但差异不显著。不同基因型rs2274907的Omentin水平在健康受试者中存在差异(p0.05)。结论:本研究显示rs2274907基因型与2型糖尿病无显著相关性。
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Association of rs2274907 polymorphism of omentin gene with type 2 diabetes in Iranian population
Background: Diabetes is one of the most common chronic metabolic diseases in the world that is caused by decreased insulin secretion or insulin resistance and fat accumulation in visceral adipose tissue (IR). Omentin is a protein inferred from adipose tissue that is associated with the rate of diabetes. The aim of this study was to investigate the relationship between rs2274907 polymorphism of amentine-1 gene with diabetes. Materials and methods: This case-control study was conducted on 70 patients with diabetes and 70 healthy individuals as control. FBS, TG, CHOL, HDL, and LDL were measured in the subjects and genotype determination was performed using PCR-RFLP. Results: Age, body mass index, LDL, cholesterol, triglyceride, fasting high sugar and insulin resistance were significantly different between patients and healthy individuals (p<0.05). No significant difference was observed in omentin level in diabetic compared to control patients (p>0.05). Omentin levels in different genotypes rs2274907 were different in healthy subjects, but the difference was not significant. Omentin levels in different genotypes rs2274907 were different in healthy subjects (p<0.05). Genotype regression analysis showed that genotypes in rs2274907 polymorphism were not related to diabetes (p>0.05). Conclusion: This study revealed that there was no significant relationship between rs2274907 genotype and type 2 diabetes.
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