脂联素水平与肥胖作为过敏疾病危险因素的相关性

M. Spasovska, T. Panovska
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摘要

许多研究都集中在两种炎症状况,过敏反应和肥胖之间的联系上,这导致了对脂联素的关注,脂联素是脂肪组织分泌的一种具有抗炎特性的激素。本研究的目的是确定脂联素与肥胖的关系,作为过敏性疾病发展的危险因素,以使其治疗方法合理化。炎症标志物和生化参数的研究方法涉及免疫测定技术。采用Student’s t检验、Wilcoxon t检验和相关系数进行统计学分析。该研究包括表面健康的受试者和确认存在特定IgE的过敏患者,根据他们的身体质量指数(BMI)分为两组。所得数据显示脂联素水平与BMI值呈负相关(cor = - 0.6)。因此,脂联素水平的降低与BMI的增加有关。研究人群脂联素均值,组间差异有统计学意义(19.1±1.5;17.7±0.9),(18.8±1.1);16.6±1.0)表明低脂联素水平与肥胖的发展之间存在关系,进而增加发生过敏性疾病的风险。假设脂联素可以作为过敏反应早期诊断的敏感生化标志物。关键词:脂联素,过敏反应,肥胖,特异性IgE
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Correlation between adiponectin level and obesity as a risk factor for allergy disease
Much research has focused on the connection between two inflammatory conditions, allergic reactions and obesity which has led to a focus on adiponectin, hormone with anti-inflammatory properties secreted by adipose tissue. The aim of this study was to determine the association of adiponectin with obesity, as a risk factor for the development of allergic condition in order to rationalize approach to its treatment. Research methods for inflammatory markers and biochemical parameters involve immunoassay technique. Statistical analysis was performed with Student’s t-test, Wilcoxon T-test and coefficient of correlation. The study included apparently healthy subjects and patients with allergy conditions with confirmed presence of specific IgE, classified into 2 groups according to their body mass index (BMI). The obtained data showed negative correlation (cor = – 0.6), between adiponectin levels and BMI values. Thus, decreased level of adiponectin is associated with increased BMI. The mean values of adiponectin in the studied population, with high statistical differen­ces between the groups (19.1 ± 1.5; 17.7 ± 0.9), (18.8± 1.1; 16.6 ± 1.0) demonstrated the relationship between low adiponectin level and development of obesity, and what, in turn, increasd risk of developing allergic conditions. The assumption was made that adiponectin may be used as a sensitive biochemical marker for early diagnostics of allergic reactions. Keywords: adiponectin, allergy reactions, obesity, specific IgE
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