表观遗传特征是心力衰竭表型的关键吗

A. Berezin
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引用次数: 1

摘要

慢性心力衰竭(HF)是一个主要的临床和公共问题,在不同人群中具有较高的发病率和死亡率。HF似乎有两种表型形式:左心室射血分数(HFrEF)降低的HF和左心室射血分数(HFpEF)保持的HF。尽管两种HF表型在临床特征、合并症状态、预测评分和治疗方面存在差异,但HFrEF和HFpEF患者的临床结局相似。在这种情况下,研究导致两种HF表型发展和进展的各种分子和细胞机制是非常重要的。越来越多的证据表明,表观遗传调控可能在心衰的发病机制中有一定的线索。该综述代表了目前可获得的关于表观遗传修饰在不同HF表型发展中的含义的证据。
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Are Epigenetic Features Essential in Advance of Heart Failure Phenotypes
Chronic heart failure (HF) is a leading clinical and public problem affected higher risk of morbidity and mortality in different population. HF appears to be in both phenotypic forms: HF with reduced left ventricular ejection fraction (HFrEF) and HF with preserved left ventricular ejection fraction (HFpEF). Although both HF phenotypes are distinguished in clinical features, co-morbidity status, prediction score, and treatment, the clinical outcomes in patients with HFrEF and HFpEF are similar. In this context investigation of various molecular and cellular mechanisms leading to development and progression of both HF phenotypes are very important. There is emerging evidence regarding that the epigenetic regulation may have a clue in the pathogenesis of HF. The review is represented current available evidence regarding an implication of epigenetic modifications in development of different HF phenotypes.
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