2型糖尿病女性性功能障碍:一项观察性研究

Manisha Gupta, R. Shukla, S. Verma, A. Kalhan
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引用次数: 1

摘要

导言:尽管有轶事证据表明血糖控制与女性性健康之间存在关联,但目前缺乏评估2型糖尿病(T2DM)女性性功能障碍的研究。材料和方法:在一个地区糖尿病中心进行了一项观察性横断面研究,对100名女性T2DM患者进行了随访。采用有效问卷、女性性功能指数(FSFI)和女性性困扰量表(FSDS)对被试女性性功能障碍(FSD)的患病率和严重程度进行整理。分别通过临床检查和血液检查记录人体测量和代谢参数。结果:研究中18% (95% CI: 10.5-25.5%)的女性发生FSD。FSD患者年龄明显偏大(50±9.3岁vs 43.9±8.2岁,P = 0.006)。此外,FSD患者的平均体重指数(BMI)(31.96±5.5 Kg/m2比28.98±4.63Kg/m2, P = 0.02)和腰围(38.88±6.6英寸比35.54±5.62英寸,P = 0.03)均高于非FSD患者。然而,我们观察到FSD与糖尿病病程、血糖控制水平和血清睾酮水平之间没有统计学上的显著关联。结论:高龄、较高的BMI和中枢性肥胖与FSD的发生有关,而糖尿病病程和HbA1c水平不增加FSD的发生风险。
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Sexual dysfunction in women with type 2 diabetes mellitus: An observational study
Introduction: There is a dearth of studies evaluating sexual dysfunction in women with Type 2 Diabetes Mellitus (T2DM), despite anecdotal evidence suggesting an association between glycemic control and female sexual health. Materials and Methods: An observational cross-sectional study was carried out in 100 women with T2DM under follow-up at a regional diabetes center. Validated questionnaires, Female Sexual Function Index (FSFI), and Female Sexual Distress Scale (FSDS) were used to collate the prevalence and severity of female sexual dysfunction (FSD) in the subjects. Anthropometric and metabolic parameters were recorded by clinical examination and blood tests, respectively. Results: FSD was reported in 18% (95% CI: 10.5–25.5%) of the women enrolled in the study. The women with FSD were significantly older (50 ± 9.3 years vs. 43.9 ± 8.2 years, P = 0.006). In addition, the mean body mass index (BMI) (31.96 ± 5.5 Kg/m2 vs. 28.98 ± 4.63Kg/m2, P = 0.02) and waist circumference (38.88 ± 6.6 inches vs. 35.54 ± 5.62 inches, P = 0.03) were higher in the women with FSD compared with those without FSD. However, we observed no statistically significant association between FSD and the duration of diabetes, level of glycemic control, and serum testosterone level. Conclusion: Advanced age, higher BMI, and central adiposity were related with the development of FSD, whereas the duration of diabetes and level of HbA1c did not increase FSD risk.
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