局部复发性转移性子宫平滑肌瘤围手术期经导管栓塞治疗

I. Alagkiozidis, G. Salame, Jonathan Somma, M. Herskovitz, D. Levin
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摘要

代表子宫肌瘤初始诊断后子宫外平滑肌瘤病变的不同大小和位置和不同延迟的表现。自1939年首次报道以来,良性转移性平滑肌瘤的性质一直存在争议,英国文献中仅报道了几十例1。最近在蛋白质组学和基因组水平上的研究结果表明,转移性病变与原发性子宫肌瘤有克隆关系,并表明其发病机制依赖于转移扩散,而不是同时出现多灶性2。因此,这些肿瘤可视为交界性肿瘤或低恶性潜能肿瘤。由于这些病例的罕见性,目前对其管理尚无共识。雌激素(ER)和孕酮(PR)受体的高表达支持激素治疗的使用。由于这些肿瘤的复发性、弥散性及其异常的血管分布,手术干预可能具有挑战性。在过去的几十年里,子宫动脉栓塞已经成为原发性子宫肌瘤的一种成熟的治疗方法。本病例提示在BML患者的治疗中应考虑血管造影和栓塞,以避免手术干预或降低围手术期出血的风险。
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Perioperative transcatheter embolisation of a locally recurrent metastatic uterine leiomyoma
representing extra-uterine foci of leiomyomatous lesions of variable size and locations and variable delay in presentation after initial diagnosis of uterine fibroids. The nature of benign metastasizing leiomyoma has been debated since it was first reported in 1939, and only a few dozen cases have been reported in the English literature 1 . Recent findings at the proteomic and genomic level demonstrate that the metastatic lesions are clonally related to the primary uterine fibroids and suggest that their pathogenesis relies on metastatic spread and not on simultaneous multifocal appearance 2 . Therefore, these tumours could be regarded as borderline tumours or tumours with low malignant potential. Due to the rarity of these cases, there is currently no consensus on their management. The high expression of oestrogen (ER) and progesterone (PR) receptors supports the use of hormonal therapy. Surgical intervention can be challenging due to the recurrent, often disseminated nature of these tumours and their aberrant vascularity. Over the last few decades, uterine artery embolisation has emerged as an established treatment for primary uterine fibroids. This case suggests that angiography and embolisation should be considered in the management of the patients with BML in an attempt to avoid surgical intervention or decrease the risk for perioperative bleeding.
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