植物化合物LCS101对化疗细胞毒性的影响

Z. Cohen, Y. Maimon, N. Samuels, R. Berger
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摘要

许多肿瘤患者报告在接受化疗时使用植物药。关于“天然”产物与化疗药物之间相互作用的研究相对较少,这涉及到常规治疗的安全性和有效性。LCS101是一种植物配方,已被证明可以减少严重贫血和中性粒细胞减少症的发生率,以及乳腺癌化疗方案引起的不良事件。该配方还被证明可以增强阿霉素和氟尿嘧啶(5-FU)对乳腺癌细胞系的抗癌作用,同时保护非致瘤性乳腺细胞免于细胞死亡。本研究旨在进一步研究LCS101对化疗的影响,这次使用吉西他滨、顺铂、紫杉醇和依托泊苷。为此,将肺癌(A549)、乳腺癌(MCF7)、胰腺癌(PANC-1)和膀胱癌(T24)细胞系暴露于四种化疗药物中每一种的浓度增加,并添加或不添加固定剂量的LCS101。采用硫代丹胺B (SRB)法测定细胞活力。植物配方的添加被发现显著增强了每种化疗药物的细胞毒性作用,这在所有四种癌细胞系中都是如此。这些发现进一步支持了先前关于LCS101与化疗之间潜在相互作用的研究。进一步的研究正在进行中,以检验这种和其他植物制剂作为常规肿瘤治疗辅助手段的意义。
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Effect of the Botanical Compound LCS101 on Cytotoxicity of Chemotherapy
Many oncology patients report using botanicals while undergoing chemotherapy. There are relatively few studies on the interactions between “natural” products and chemotherapy agents, with implications regarding safety and efficacy of the conventional treatment. LCS101 is a botanical formula which has been shown to reduce the incidence of severe anemia and neutropenia, as well adverse events resulting from chemotherapy regimens for breast cancer. The formula has also been shown to increase the anti-cancer effects of doxorubicin and fluorouracil (5-FU) on breast cancer cell lines, while protecting non-tumorigenic breast cells from cell death. The present study set out to further examine the effects of LCS101 on chemotherapy, this time with gemcitabine, cisplatin, paclitaxel and etoposide. For this purpose, lung (A549), breast (MCF7), pancreatic (PANC-1) and bladder (T24) cancer cell lines were exposed to incremental concentrations of each of the four chemotherapy agents, with and without the addition of fixed dose of LCS101. A sulforhodamine B (SRB) assay was used to assess cell viability. The addition of the botanical formula was found to significantly augment the cytotoxic effects of each of the chemotherapy agents, this in all four cancer cell lines. These findings further support those of previous research on potential interactions between LCS101 with chemotherapy. Additional research is underway to examine the implications of this and other botanical formulas as an adjunct to conventional oncology treatments.
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