一项多中心横断面研究:体重指数与修正主观整体评估在维持性血液透析患者中检测营养不良的比较

Mohammad Syfur Rahman, M. Haque, Tayeba Sultana, T. Sultana, Syed Asif Ul Alam
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引用次数: 0

摘要

背景:维持性血液透析患者营养不良的风险增加,这是由多种因素引起的。本研究旨在通过改良的主观总体评估评分和体重指数来评估维持性血液透析患者营养不良的发生率,并对两者进行比较,评估体重指数检测营养不良的敏感性和特异性,同时确定一个新的BMI临界值,更好地代表维持性血液透析患者的营养状况。方法:这是一项横断面研究,在Bangabandhu Sheikh Mujib医科大学、Sir Salimullah医学院Mitford医院、BIRDEM总医院和国家肾脏疾病和泌尿外科研究所的血液透析部门进行;在2016年7月至2017年6月期间,80名定期(每周≥2次)维持性血液透析超过3个月且未发生急性感染的成人CKD患者。采用改良SGA评分和BMI对每位患者进行营养评估。使用改良SGA评分作为检测应答者营养不良的金标准测试,对研究人群中WHO推荐的BMI临界值进行敏感性分析。采用ROC曲线估计BMI的最佳拟合截止值,该值对减损维持性血液透析患者的营养不良具有最高的敏感性、特异性和准确性。结果:研究参与者以男性为主(66.3%),年龄在45 - 59岁之间(36.3%)。改良的SGA评分检测出90.0%的研究人群营养不良。世卫组织推荐的18.5 kg/m2临界值也被用于检测研究人群的营养不良,发现13.8%的人营养不良,敏感性和特异性分别为12.5%和75.0%。准确率为18.8%。通过ROC曲线,发现23.1 kg/m2是研究人群BMI检测营养不良的最佳拟合截止值。敏感性47.2%,特异性37.5%,准确性46.3%。结论:与改良SGA评分相比,BMI在检测维持性血液透析患者营养不良方面的敏感性较低,不宜作为筛查工具,但BMI的23.1 kg/m2临界值有可能作为一种简便快捷的检测维持性血液透析患者营养不良的工具。更大样本量的进一步研究可能会对这一点有更多的了解。JOPSOM 2021;(1): 40的程度
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Comparison of Body Mass Index with Modified Subjective Global Assessment for Detection of Malnutrition Among Patients Under Maintenance Hemodialysis: A Multi-Center Cross-Sectional Study
Background: Patients under maintenance hemodialysis are at increased risk of malnutrition, causing from multitude of factors. Present study aims to assess the prevalence of malnutrition among maintenance hemodialysis patients using both modified subjective global assessment score and body mass index, compare them and assess the sensitivity and specificity of body mass index for detecting malnutrition, along with determining a new cutoff value for BMI that better represent the maintenance hemodialysis patient’s nutritional status. Methods: This was a cross-sectional study conducted in the hemodialysis unit of Bangabandhu Sheikh Mujib Medical University, Sir Salimullah Medical College Mitford Hospital, BIRDEM General Hospital and National Institute of Kidney Diseases & Urology; among 80 adult CKD patients who were on regular (≥2 sessions per week) maintenance hemodialysis for more than 3 months without any acute infection, during the period of July 2016 to June 2017. Nutritional assessment was done for each patient using modified SGA score along with BMI. Sensitivity analysis of WHO recommended cutoff value for BMI was done among the study population using modified SGA score as gold standard test for detection of malnutrition among the respondents. ROC curve was used to estimate the best fitting cutoff value of BMI that showed highest sensitivity, specificity and accuracy for detracting malnutrition among maintenance hemodialysis patients. Results: The study participants were predominantly male (66.3%) and from age group 45 to 59 years (36.3%). Modified SGA score detected 90.0% of the study population as malnourished. WHO recommended 18.5 kg/m2 cutoff value was also used to detect malnutrition among study population and 13.8% were found to be malnourished, with a sensitivity and specificity of 12.5% and 75.0% respectively. Accuracy was found to be 18.8%. Using ROC curve, 23.1 kg/m2 was found to be the best fitting cutoff value of BMI for the study population to detect malnutrition. With a sensitivity of 47.2%, specificity of 37.5% and accuracy of 46.3%. Conclusion: BMI showed low sensitivity for detecting malnutrition among patients under maintenance hemodialysis, compared to modified SGA score and should be avoided as a screening tool, but 23.1 kg/m2 cutoff value for BMI showed potential to be used as an easy to use and quick tool for detecting malnutrition among such patients. Further study with larger sample size could shed more light on this. JOPSOM 2021; 40(1): 14-21
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