促红细胞生成素治疗中枢神经系统疾病的观点

Liuzhu Yang, Ruizhen Li, Bo Wu, Jinau Luo, Zhong Chen, Xin-Ping, Yan, Wei Tan
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引用次数: 1

摘要

脊髓损伤是一个复杂的过程,导致神经组织和血管结构的破坏。近年来许多研究表明,促红细胞生成素(EPO)在急性脊髓损伤动物模型中具有神经保护作用。阿尔茨海默病(Alzheimer 's disease, AD)、帕金森病(Parkinson 's disease, PD)和脊髓损伤(SCI)属于中枢神经系统疾病,少数研究也表明EPO可能对AD和PD有效。在这篇简短的综述文章中,我们简要概述了rhEPO在SCI, AD和PD中的动物和人类研究。进一步的临床研究应该揭示EPO的衍生物和变体是否比实验研究中EPO在治疗SCI、AD和PD方面的临床应用有任何益处。
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Point of View about Erythropoietin in Treatment of Central NervousSystem Diseases
Spinal Cord Injury (SCI) is a complex process which leads to destruction of neuronal tissue and also vascular structure. Recent many studies have shown erythropoietin (EPO) has neuro-protective effects in acute SCI animal models. Alzheimer’s disease (AD), Parkinson’s disease (PD) and SCI belong to central nervous system diseases, a few studies also indicated that EPO may be effective for AD and PD. In this a short review article, we provide a short overview of the animal and human studies on rhEPO in SCI, AD and PD. Further clinical studies should reveal whether derivatives and variants of EPO provide any benefits over the clinical application EPO to against SCI, AD and PD in the experimental studies.
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