Chocs anaphylactiques présumés d’origine médicamenteuse ou au latex chez l’adulte : enquête au CHU de Clermont-Ferrand de 1999 à 2005

Sixty-one adults with drug-induced anaphylactic shocks were admitted to the Teaching Hospital of Clermont-Ferrand between 1st January 1999 and 31st December 2005. The patients included in the study were identified on the basis of tryptase assay requested by the Laboratory of Immunology during that period. The study focuses on the epidemiology and aetiology of the anaphylactic shocks but also on their diagnosis and in particular the allergic investigation, which should be performed at least six weeks after the accident: in all, 14 patients were seen. Another aspect of the study concerns the diagnostic significance of the tryptase assay compared to the allergy results available and the clinical severity of the observations. The survey compares findings from the Laboratory of Immunology and the Hospital Allergy Department with cases noticed by the Regional Center of Drug Surveillance to improve the management of patients with a story of anaphylactic shock.