转移和扩散的进化

Tazzio Tissot, F. Massol, B. Ujvari, C. Alix-Panabières, N. Loeuille, F. Thomas
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引用次数: 15

摘要

尽管肿瘤学取得了重大进展,但转移仍然是癌症患者死亡的主要原因。了解这种现象的基础可以帮助控制甚至预防它。正如许多生态学家和癌症生物学家所建议的那样,转移可以从生物扩散的角度来考虑:癌细胞从其出生部位(原发肿瘤)移动到其他栖息地,在那里它们恢复增殖(转移部位)。然而,该模型是否能够一致地应用于转移的出现和动态尚不清楚。在这里,我们提供了生态系统中扩散进化的各个方面的广泛回顾。我们研究了类似的生态和进化原理是否可以应用于转移,以及这些过程如何影响癌细胞传播的时空动态。我们进一步讨论了互补的假设,并提出了实验方法来测试扩散在研究转移中的进化生态学的相关性。
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Metastasis and the evolution of dispersal
Despite significant progress in oncology, metastasis remains the leading cause of mortality of cancer patients. Understanding the foundations of this phenomenon could help contain or even prevent it. As suggested by many ecologists and cancer biologists, metastasis could be considered through the lens of biological dispersal: the movement of cancer cells from their birth site (the primary tumour) to other habitats where they resume proliferation (metastatic sites). However, whether this model can consistently be applied to the emergence and dynamics of metastasis remains unclear. Here, we provide a broad review of various aspects of the evolution of dispersal in ecosystems. We investigate whether similar ecological and evolutionary principles can be applied to metastasis, and how these processes may shape the spatio-temporal dynamics of disseminating cancer cells. We further discuss complementary hypotheses and propose experimental approaches to test the relevance of the evolutionary ecology of dispersal in studying metastasis.
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