健康老龄化:回顾促进老年人健康的挑战、机遇和努力

A. Mehanna
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Consistent evidence from observational studies estimates that one-third of Alzheimer disease cases worldwide are attributable to seven common modifiable risk factors: diabetes mellitus, midlife hypertension, midlife obesity, physical inactivity, depression, smoking and low education. Evidence from the multidomain clinical trials of dementia preventive interventions suggests that targeting these risk factors in individuals who are at an increased risk of dementia is an effective strategy. According to a recent systematic review on the prevalence of dementia in Egypt (2017), the prevalence of dementia ranged from 2.01% to 5.07%. Dementia increased with age, with the rapid increase among those aging ≥80. Also, its prevalence was higher among illiterate groups than among educated groups. There is an urgent need for the implementation of a national policy for elderly care in Egypt. 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引用次数: 0

摘要

世界上每个国家都在经历人口规模和老年人比例的增长。虽然一个国家人口向老年化分布的这种转变——即所谓的人口老龄化——始于高收入国家,但现在正在经历最大变化的是低收入和中等收入国家。本文回顾了促进老年人健康的挑战、机遇和努力。世界卫生组织将健康老龄化定义为“发展和维持老年人健康的功能能力的过程”。功能能力包括个体的内在能力、相关环境特征及其相互作用。能够生活在支持和维持个人内在能力和功能能力的环境中,是健康老龄化的关键。事实上,人们童年生活的环境——甚至是发育中的胎儿——与他们的个人特征相结合,对他们的年龄有长期的影响。老年人遭受社会孤立、孤独和虐待老年人等社会心理问题。他们还容易患痴呆症,这是认知障碍的最严重表现,是老年人残疾的主要原因。阿尔茨海默病(AD)引起的神经退行性变是大多数痴呆症的基础,脑血管疾病(CVD)是第二大常见原因。来自观察性研究的一致证据估计,全世界三分之一的阿尔茨海默病病例可归因于七个常见的可改变的风险因素:糖尿病、中年高血压、中年肥胖、缺乏体育活动、抑郁、吸烟和受教育程度低。来自痴呆症预防干预的多领域临床试验的证据表明,针对痴呆症风险增加的个体的这些危险因素是一种有效的策略。根据最近一项关于埃及痴呆症患病率的系统综述(2017年),痴呆症患病率在2.01%至5.07%之间。老年痴呆随着年龄的增长而增加,在年龄≥80岁的人群中增加迅速。此外,它在文盲群体中的患病率高于受过教育群体。埃及迫切需要执行一项老年人护理国家政策。虽然存在这种政策,但必须评价现有政策的效力和国家委员会的作用,以便恢复和调动现有的资源。埃及神经毒理学家、全球脑健康研究所(GBHI)脑健康公平大西洋高级研究员穆罕默德·萨拉马(Mohamed Salama)认为,埃及还没有做好应对人口老龄化的准备。虽然欧洲、北美以及最近的印度、中国和拉丁美洲都有痴呆症的区域特定风险因素,但中东和北非(MENA)地区没有此类数据来指导痴呆症预防战略。在这种背景下,Mohamed一直在发展“埃及健康老龄化纵向研究”(AL-SEHA)的愿景,这可以改革埃及的研究基础设施,并支持决策者应对人口老龄化的挑战。
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Healthy Ageing: Reviewing the Challenges, Opportunities, and Efforts to Promote Health Among Old People
Every country in the world is experiencing growth in both the size and the proportion of older persons in the population. While this shift in distribution of a country's population towards older ages – known as population ageing – started in high-income countries, it is now low- and middle-income countries that are experiencing the greatest change. This article reviews the challenges, opportunities and efforts to promote health among older people. The WHO defines healthy ageing as “the process of developing and maintaining the functional ability that enables wellbeing in older age.” Functional ability consists of the intrinsic capacity of the individual, relevant environmental characteristics and the interaction between them. Being able to live in environments that support and maintain one’s intrinsic capacity and functional ability is key to healthy ageing. In fact, the environments that people live in as children – or even as developing fetuses – combined with their personal characteristics, have long-term effects on how they age. Older people suffer from psychosocial problems as social isolation, loneliness, and elder abuse. They are also subject to dementia, the most severe expression of cognitive impairment, which represents the main cause of disability in elderly people. Neurodegeneration due to Alzheimer disease (AD) underlies most of the dementia, with cerebrovascular disease (CVD) presenting the second-most common cause. Consistent evidence from observational studies estimates that one-third of Alzheimer disease cases worldwide are attributable to seven common modifiable risk factors: diabetes mellitus, midlife hypertension, midlife obesity, physical inactivity, depression, smoking and low education. Evidence from the multidomain clinical trials of dementia preventive interventions suggests that targeting these risk factors in individuals who are at an increased risk of dementia is an effective strategy. According to a recent systematic review on the prevalence of dementia in Egypt (2017), the prevalence of dementia ranged from 2.01% to 5.07%. Dementia increased with age, with the rapid increase among those aging ≥80. Also, its prevalence was higher among illiterate groups than among educated groups. There is an urgent need for the implementation of a national policy for elderly care in Egypt. Although such policies exist, the effectiveness of existing policies and the role of national committees need to be evaluated in order to revive and mobilize the resources available. Mohamed Salama, an Egyptian neurotoxicologist and Atlantic Senior Fellow for Equity in Brain Health at the Global Brain Health Institute (GBHI), believes Egypt is unprepared for demographic ageing. While region-specific risk factors for dementia are available for Europe, North America and more recently for India, China, and Latin America, the Middle Eastern and Northern African (MENA) region has no such data to guide strategies for dementia prevention. In this context, Mohamed has been developing the vision for ‘A Longitudinal Study of Egyptian Healthy Ageing’ (AL-SEHA), which could reform the Egyptian research infrastructure and support policy-makers to address the challenges of demographic ageing.
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