The changing interstitial dialectic

Interstitial cystitis (IC) does indeed appear linked to neurogenic inflammation. A direct link to substance P/neurokinin 1 receptor is unproven but highly suggested by the literature. Patients with IC may have a propensity to develop chronic inflammatory bladder disease from usually benign events. The inability of the urothelium to repair itself leaves it open to neurogenic inflammation. Neurogenic inflammation may also have its origin in the brain and not only in the dorsal root ganglion or spinal cord. IC may be promulgated by neurogenic inflammation. If this is the case, then early detection is crucial to prevent central pain.