埃及非伤寒沙门氏菌的耐药性

Khairy Rmm
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引用次数: 4

摘要

非伤寒沙门氏菌病(NTS)是由多种沙门氏菌引起的,而不是伤寒和副伤寒,[1]。NTS生物是食物中常见的污染物。据报道,禽肉、蛋、奶、蔬菜和水是人类沙门氏菌感染暴发的重要来源,仅家禽就占沙门氏菌病暴发的50%[2,3]。野生动物、啮齿动物、鸟类和爬行动物也可携带,通常无症状[1]。这些感染被确定为发达国家和发展中国家最常见的食源性人畜共患感染之一,但各国之间的发病率各不相同[4]。在埃及,NTS在家禽中的感染在过去几年中有所增加[5]。在人畜共患感染中过度使用抗生素,导致细菌产生耐药性,这种耐药性可通过三种途径传播给人类,即与动物直接接触、食用蛋类和肉类或通过环境传播[6]。对某些抗生素的耐药性,如四环素或氯霉素,对儿童的治疗是一个很大的挑战,因为氟喹诺酮类药物不应该在这个年龄组使用[7]。为确定伤寒沙门氏菌的流行和多药耐药性进行了几项研究,但在非洲国家,特别是在埃及,关于NTS的现有数据很少。Shokry等人,2015年为NTS在埃及的流行和多药耐药提供了重要见解[8]。
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Anti-Microbial Resistance of Non-Typhoid Salmonella in Egypt
Nontyphoidal salmonellosis (NTS) is caused by numerous Salmonella species other than serovars Typhi and Paratyphi, [1]. NTS organisms are common contaminants of food. Poultry meat, eggs, milk, vegetables, and water have been reported as important sources for outbreaks of human Salmonella infection, poultry alone, accounting for up to 50% of salmonellosis outbreaks [2,3].They are also carried by wild animals, rodents, birds, and reptiles, usually with no symptomatic disease [1]. These infections are identified as one of the most common food-borne zoonotic infection in developed and developing countries, but incidence between countries is variable[4]. In Egypt, NTS infections in poultry have increased in the last years [5]. There are excessive uses of antibiotics in zoonotic infections resulting in development of bacterial resistance that can be transmitted to humans by three ways, from direct contact with animals, from the consumption of eggs and meat or through the environment [6]. The resistance to some antibiotics, such as tetracycline, or chloramphenicol is a big challenge for the treatment of children because fluoroquinolons should not be used in this age group [7]. Several studies were performed to determine the prevalence and multidrug resistance of typhoidal salmonella but the existing data about NTS are little in African countries especially in Egypt. Shokry et al., 2015 provides important insight into prevalence and multidrug resistance of NTS in Egypt [8].
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