С. Г. Пашкевич, С. П. Рубникович, Т. Е. Кузнецова, Е. В. Кузьменко, Г. П. Миронова, О. Г. Тихонович, Ж. А. Гладкова, К. Н. Жогаль, Н. С. Сердюченко, А. С. Грищенков, S. Pashkevich, Sergey P . Rubnikovich, Tatyana E . Kuznetsova, Elena V . Kuzmenko, Galina P . Mironova, Olga G . Tikhonovich, Zhanna A. Gladkova, Kseniya N . Zhogal, N. S. Serdyuchenko, Arseny S . Grishchenkov
{"title":"间充质干细胞用于颞下颌关节炎症模型后实验动物脑形态结构的变化","authors":"С. Г. Пашкевич, С. П. Рубникович, Т. Е. Кузнецова, Е. В. Кузьменко, Г. П. Миронова, О. Г. Тихонович, Ж. А. Гладкова, К. Н. Жогаль, Н. С. Сердюченко, А. С. Грищенков, S. Pashkevich, Sergey P . Rubnikovich, Tatyana E . Kuznetsova, Elena V . Kuzmenko, Galina P . Mironova, Olga G . Tikhonovich, Zhanna A. Gladkova, Kseniya N . Zhogal, N. S. Serdyuchenko, Arseny S . Grishchenkov","doi":"10.29235/1814-6023-2023-20-3-216-225","DOIUrl":null,"url":null,"abstract":"The article presents the results of structural and functional transformations in cerebellum, trigeminal nuclei, and hippocampus of male Wistar rats against the background of injection of mesenchymal stem cells (MSCs) into Meckel’s space in the temporomandibular joint (TMJ) inflammation model.The aim of the study was to clarify the effect of MSCs injections into Meckel’s space on the morphostructural features of cerebellum, trigeminal nuclei, and hippocampus in the TMJ inflammation model.Injecting the mesenchymal stem cells into Meckel’s space in an inflammatory model of the right lower temporomandibular joint promotes the structure restoration of the ganglionic layer of the cerebellum, the spinal nuclei of the trigeminal nerve, and the hippocampus of rats by the 28th day. This is manifested in increasing the neuronal density, decreasing the neurodegeneration index, and in activating glia elements.","PeriodicalId":20584,"journal":{"name":"Proceedings of the National Academy of Sciences of Belarus, Medical series","volume":"92 1","pages":""},"PeriodicalIF":0.0000,"publicationDate":"2023-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Morphostructural changes in the brain of experimental animals after using mesenchymal stem cells in the temporomandibular joint inflammation model\",\"authors\":\"С. Г. Пашкевич, С. П. Рубникович, Т. Е. Кузнецова, Е. В. Кузьменко, Г. П. Миронова, О. Г. Тихонович, Ж. А. Гладкова, К. Н. Жогаль, Н. С. Сердюченко, А. С. Грищенков, S. Pashkevich, Sergey P . Rubnikovich, Tatyana E . Kuznetsova, Elena V . Kuzmenko, Galina P . Mironova, Olga G . Tikhonovich, Zhanna A. Gladkova, Kseniya N . Zhogal, N. S. Serdyuchenko, Arseny S . Grishchenkov\",\"doi\":\"10.29235/1814-6023-2023-20-3-216-225\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"The article presents the results of structural and functional transformations in cerebellum, trigeminal nuclei, and hippocampus of male Wistar rats against the background of injection of mesenchymal stem cells (MSCs) into Meckel’s space in the temporomandibular joint (TMJ) inflammation model.The aim of the study was to clarify the effect of MSCs injections into Meckel’s space on the morphostructural features of cerebellum, trigeminal nuclei, and hippocampus in the TMJ inflammation model.Injecting the mesenchymal stem cells into Meckel’s space in an inflammatory model of the right lower temporomandibular joint promotes the structure restoration of the ganglionic layer of the cerebellum, the spinal nuclei of the trigeminal nerve, and the hippocampus of rats by the 28th day. This is manifested in increasing the neuronal density, decreasing the neurodegeneration index, and in activating glia elements.\",\"PeriodicalId\":20584,\"journal\":{\"name\":\"Proceedings of the National Academy of Sciences of Belarus, Medical series\",\"volume\":\"92 1\",\"pages\":\"\"},\"PeriodicalIF\":0.0000,\"publicationDate\":\"2023-09-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Proceedings of the National Academy of Sciences of Belarus, Medical series\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://doi.org/10.29235/1814-6023-2023-20-3-216-225\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q4\",\"JCRName\":\"Medicine\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Proceedings of the National Academy of Sciences of Belarus, Medical series","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.29235/1814-6023-2023-20-3-216-225","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q4","JCRName":"Medicine","Score":null,"Total":0}
Morphostructural changes in the brain of experimental animals after using mesenchymal stem cells in the temporomandibular joint inflammation model
The article presents the results of structural and functional transformations in cerebellum, trigeminal nuclei, and hippocampus of male Wistar rats against the background of injection of mesenchymal stem cells (MSCs) into Meckel’s space in the temporomandibular joint (TMJ) inflammation model.The aim of the study was to clarify the effect of MSCs injections into Meckel’s space on the morphostructural features of cerebellum, trigeminal nuclei, and hippocampus in the TMJ inflammation model.Injecting the mesenchymal stem cells into Meckel’s space in an inflammatory model of the right lower temporomandibular joint promotes the structure restoration of the ganglionic layer of the cerebellum, the spinal nuclei of the trigeminal nerve, and the hippocampus of rats by the 28th day. This is manifested in increasing the neuronal density, decreasing the neurodegeneration index, and in activating glia elements.
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