Effect of Timolol application time on refractive regression after LASIK in patients with high myopia

Objective To observe the effect of application time of Timolol eye drops on refractive regression after LASIK in patients with high myopia. Methods A prospective case study.The data of 64 eyes of 32 patients with high myopia who underwent LASIK from Jan.2017 to Dec.2018 in the First Affiliated Hospital of Zhengzhou University were analyzed.All cases were randomly divided into the clinical trial group and the control group, 32 eyes of 32 cases in each group.All cases were selected one eye after surgery as the observation object.All cases received the conventional antibiotic eye drops combined with Timolol eye drops at 1 day after surgery.The Timolol eye drops in trial group were continuously dripped for 3 months, and the control group were dripped for 1 month.The two groups were followed up for 6 months. Results There was no significant difference in the visual acuity, intraocular pressure, refractive status equivalent spherical degree (SE) and corneal anterior shift (Diff value) between the two groups at 1 week and 1 month after operation(P>0.05). The difference of uncorrected visual acuity, refractive status (SE) and corneal anterior volume in the clinical trial group at 3 and 6 months after operation were better than those in the control group (t=7.030, 3.250, P=0.000, 0.010). Conclusion Application of Timolol eye drops after LASIK for 3 months can prevent refractive retraction after high myopia. Key words: Myopia, high; LASIK; Regression, refractive; Timolol; Pressure, intraocular