伊朗西北地区妇女HLA-G基因rs1632943和rs1736932多态性与复发性流产的关系

Baharak Ebrahimi Behnam, mohammad khalaj kondori, mohammad ali Hoseinpour Feizi
{"title":"伊朗西北地区妇女HLA-G基因rs1632943和rs1736932多态性与复发性流产的关系","authors":"Baharak Ebrahimi Behnam, mohammad khalaj kondori, mohammad ali Hoseinpour Feizi","doi":"10.52547/sjku.26.6.82","DOIUrl":null,"url":null,"abstract":"Background and Aim: Recurrent spontaneous abortion (RSA) is the most common complication of pregnancy that refers to two or more miscarriages before the 20 week of pregnancy. HLA-G immunoglobulin molecule plays an important role in protecting the fetus against mother's immune system. The aim of this study was to investigate the association between rs1632943 and rs1736932 polymorphisms with recurrent spontaneous abortion in Northwest of Iran. Materials and Methods: This case-control study included 100 women with history of RSA as our case group and 80 healthy women with one or more than one children as the control group. Genomic DNA was purified from their peripheral blood samples and their genotypes were determined by PCR-sequencing method. Using SPSS 16, statistical analysis was performed by chi-square test. Results: In rs1632943 polymorphism the frequency of CC, CA and AA genotypes were 8%, 33% and 59% in the patient group and 16.25%, 43.75% and % 40 in the control group, respectively. Statistical analysis showed that AA genotype was associated with the recurrent spontaneous abortion (P = 0.005). In the rs1736932 polymorphism, the frequency of CC, CG and GG genotypes were 8%, 32% and 60% in the patient group and 17.5%, 41.25% and 41.25% in the control group, respectively. Statistical analysis showed that GG genotype was associated with the recurrent miscarriage (P = 0.005). Also, haplotype analysis showed that H1 haplotype (GA) is associated with the disorder. Conclusion: Results of the study showed that rs1632943 and ra1736932 polymorphisms might be considered as risk factors for RSA in the women in Northwest of Iran.","PeriodicalId":21808,"journal":{"name":"Scientific Journal of Kurdistan University of Medical Sciences","volume":"114 1","pages":""},"PeriodicalIF":0.0000,"publicationDate":"2021-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Association of rs1632943 and rs1736932 Polymorphisms of HLA-G gene with Recurrent Abortion in the Women in Northwest of Iran\",\"authors\":\"Baharak Ebrahimi Behnam, mohammad khalaj kondori, mohammad ali Hoseinpour Feizi\",\"doi\":\"10.52547/sjku.26.6.82\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"Background and Aim: Recurrent spontaneous abortion (RSA) is the most common complication of pregnancy that refers to two or more miscarriages before the 20 week of pregnancy. HLA-G immunoglobulin molecule plays an important role in protecting the fetus against mother's immune system. The aim of this study was to investigate the association between rs1632943 and rs1736932 polymorphisms with recurrent spontaneous abortion in Northwest of Iran. Materials and Methods: This case-control study included 100 women with history of RSA as our case group and 80 healthy women with one or more than one children as the control group. Genomic DNA was purified from their peripheral blood samples and their genotypes were determined by PCR-sequencing method. Using SPSS 16, statistical analysis was performed by chi-square test. Results: In rs1632943 polymorphism the frequency of CC, CA and AA genotypes were 8%, 33% and 59% in the patient group and 16.25%, 43.75% and % 40 in the control group, respectively. Statistical analysis showed that AA genotype was associated with the recurrent spontaneous abortion (P = 0.005). In the rs1736932 polymorphism, the frequency of CC, CG and GG genotypes were 8%, 32% and 60% in the patient group and 17.5%, 41.25% and 41.25% in the control group, respectively. Statistical analysis showed that GG genotype was associated with the recurrent miscarriage (P = 0.005). Also, haplotype analysis showed that H1 haplotype (GA) is associated with the disorder. Conclusion: Results of the study showed that rs1632943 and ra1736932 polymorphisms might be considered as risk factors for RSA in the women in Northwest of Iran.\",\"PeriodicalId\":21808,\"journal\":{\"name\":\"Scientific Journal of Kurdistan University of Medical Sciences\",\"volume\":\"114 1\",\"pages\":\"\"},\"PeriodicalIF\":0.0000,\"publicationDate\":\"2021-12-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Scientific Journal of Kurdistan University of Medical Sciences\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://doi.org/10.52547/sjku.26.6.82\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q4\",\"JCRName\":\"Medicine\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Scientific Journal of Kurdistan University of Medical Sciences","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.52547/sjku.26.6.82","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q4","JCRName":"Medicine","Score":null,"Total":0}
引用次数: 0

摘要

背景与目的:复发性自然流产(RSA)是妊娠最常见的并发症,指妊娠20周前两次或两次以上流产。HLA-G免疫球蛋白分子在保护胎儿免受母体免疫系统攻击中起着重要作用。本研究的目的是探讨rs1632943和rs1736932多态性与伊朗西北地区复发性自然流产的关系。材料和方法:本病例对照研究纳入100例有RSA病史的妇女作为病例组,80例有一个或多个孩子的健康妇女作为对照组。从其外周血中纯化基因组DNA,采用pcr测序法测定基因型。采用spss16软件,采用卡方检验进行统计学分析。结果:rs1632943基因多态性中,CC、CA和AA基因型在患者组的频率分别为8%、33%和59%,对照组的频率分别为16.25%、43.75%和% 40%。统计分析显示AA基因型与复发性自然流产相关(P = 0.005)。rs1736932多态性中,CC、CG和GG基因型在患者组的频率分别为8%、32%和60%,对照组的频率分别为17.5%、41.25%和41.25%。GG基因型与反复流产相关(P = 0.005)。单倍型分析表明,H1单倍型(GA)与该病有关。结论:rs1632943和ra1736932多态性可能是伊朗西北地区女性RSA发病的危险因素。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
查看原文
分享 分享
微信好友 朋友圈 QQ好友 复制链接
本刊更多论文
Association of rs1632943 and rs1736932 Polymorphisms of HLA-G gene with Recurrent Abortion in the Women in Northwest of Iran
Background and Aim: Recurrent spontaneous abortion (RSA) is the most common complication of pregnancy that refers to two or more miscarriages before the 20 week of pregnancy. HLA-G immunoglobulin molecule plays an important role in protecting the fetus against mother's immune system. The aim of this study was to investigate the association between rs1632943 and rs1736932 polymorphisms with recurrent spontaneous abortion in Northwest of Iran. Materials and Methods: This case-control study included 100 women with history of RSA as our case group and 80 healthy women with one or more than one children as the control group. Genomic DNA was purified from their peripheral blood samples and their genotypes were determined by PCR-sequencing method. Using SPSS 16, statistical analysis was performed by chi-square test. Results: In rs1632943 polymorphism the frequency of CC, CA and AA genotypes were 8%, 33% and 59% in the patient group and 16.25%, 43.75% and % 40 in the control group, respectively. Statistical analysis showed that AA genotype was associated with the recurrent spontaneous abortion (P = 0.005). In the rs1736932 polymorphism, the frequency of CC, CG and GG genotypes were 8%, 32% and 60% in the patient group and 17.5%, 41.25% and 41.25% in the control group, respectively. Statistical analysis showed that GG genotype was associated with the recurrent miscarriage (P = 0.005). Also, haplotype analysis showed that H1 haplotype (GA) is associated with the disorder. Conclusion: Results of the study showed that rs1632943 and ra1736932 polymorphisms might be considered as risk factors for RSA in the women in Northwest of Iran.
求助全文
通过发布文献求助,成功后即可免费获取论文全文。 去求助
来源期刊
CiteScore
0.40
自引率
0.00%
发文量
0
审稿时长
4 weeks
期刊最新文献
Comparison the Effects of Visual Activities Schedule and Social Narratives on Social Interaction in Children with Autism Spectrum Disorder Evaluation of the efficacy of DIAGNOdent Laser in Comparison with Clinical Observation Technique in Occlusal Caries Diagnosis Relationship between Oral-Dental Health Status with Chronic Systemic Diseases and Salivary IgA Level in Elderly Population: A Systematic Review correlation between serum Vitamin D3 Level and Disease Severity in the Patients with Chronic Obstructive Pulmonary Disease (COPD) Evaluation of Pollution and Carcinogenic Risk of Heavy Metals in Agricultural Soil, Wheat and Flour in Bijar City
×
引用
GB/T 7714-2015
复制
MLA
复制
APA
复制
导出至
BibTeX EndNote RefMan NoteFirst NoteExpress
×
×
提示
您的信息不完整,为了账户安全,请先补充。
现在去补充
×
提示
您因"违规操作"
具体请查看互助需知
我知道了
×
提示
现在去查看 取消
×
提示
确定
0
微信
客服QQ
Book学术公众号 扫码关注我们
反馈
×
意见反馈
请填写您的意见或建议
请填写您的手机或邮箱
已复制链接
已复制链接
快去分享给好友吧!
我知道了
×
扫码分享
扫码分享
Book学术官方微信
Book学术文献互助
Book学术文献互助群
群 号:481959085
Book学术
文献互助 智能选刊 最新文献 互助须知 联系我们:info@booksci.cn
Book学术提供免费学术资源搜索服务,方便国内外学者检索中英文文献。致力于提供最便捷和优质的服务体验。
Copyright © 2023 Book学术 All rights reserved.
ghs 京公网安备 11010802042870号 京ICP备2023020795号-1