伊朗西北地区妇女HLA-G基因rs1632943和rs1736932多态性与复发性流产的关系

Baharak Ebrahimi Behnam, mohammad khalaj kondori, mohammad ali Hoseinpour Feizi
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引用次数: 0

摘要

背景与目的:复发性自然流产(RSA)是妊娠最常见的并发症,指妊娠20周前两次或两次以上流产。HLA-G免疫球蛋白分子在保护胎儿免受母体免疫系统攻击中起着重要作用。本研究的目的是探讨rs1632943和rs1736932多态性与伊朗西北地区复发性自然流产的关系。材料和方法:本病例对照研究纳入100例有RSA病史的妇女作为病例组,80例有一个或多个孩子的健康妇女作为对照组。从其外周血中纯化基因组DNA,采用pcr测序法测定基因型。采用spss16软件,采用卡方检验进行统计学分析。结果:rs1632943基因多态性中,CC、CA和AA基因型在患者组的频率分别为8%、33%和59%,对照组的频率分别为16.25%、43.75%和% 40%。统计分析显示AA基因型与复发性自然流产相关(P = 0.005)。rs1736932多态性中,CC、CG和GG基因型在患者组的频率分别为8%、32%和60%,对照组的频率分别为17.5%、41.25%和41.25%。GG基因型与反复流产相关(P = 0.005)。单倍型分析表明,H1单倍型(GA)与该病有关。结论:rs1632943和ra1736932多态性可能是伊朗西北地区女性RSA发病的危险因素。
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Association of rs1632943 and rs1736932 Polymorphisms of HLA-G gene with Recurrent Abortion in the Women in Northwest of Iran
Background and Aim: Recurrent spontaneous abortion (RSA) is the most common complication of pregnancy that refers to two or more miscarriages before the 20 week of pregnancy. HLA-G immunoglobulin molecule plays an important role in protecting the fetus against mother's immune system. The aim of this study was to investigate the association between rs1632943 and rs1736932 polymorphisms with recurrent spontaneous abortion in Northwest of Iran. Materials and Methods: This case-control study included 100 women with history of RSA as our case group and 80 healthy women with one or more than one children as the control group. Genomic DNA was purified from their peripheral blood samples and their genotypes were determined by PCR-sequencing method. Using SPSS 16, statistical analysis was performed by chi-square test. Results: In rs1632943 polymorphism the frequency of CC, CA and AA genotypes were 8%, 33% and 59% in the patient group and 16.25%, 43.75% and % 40 in the control group, respectively. Statistical analysis showed that AA genotype was associated with the recurrent spontaneous abortion (P = 0.005). In the rs1736932 polymorphism, the frequency of CC, CG and GG genotypes were 8%, 32% and 60% in the patient group and 17.5%, 41.25% and 41.25% in the control group, respectively. Statistical analysis showed that GG genotype was associated with the recurrent miscarriage (P = 0.005). Also, haplotype analysis showed that H1 haplotype (GA) is associated with the disorder. Conclusion: Results of the study showed that rs1632943 and ra1736932 polymorphisms might be considered as risk factors for RSA in the women in Northwest of Iran.
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