心肌梗死伴抑郁的病理生理机制及药物干预

Mingyang Xu, Yinxiang Wei, Zhenhui Wang, Yaohui Wang, Xiaoming Zhong, Qiying Chen
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引用次数: 0

摘要

徐明阳1,魏银祥2,王振辉1,王耀辉2,钟晓明3,*,陈启英4,*1河南大学医学院,开封475000 2河南大学抗体药物工程国家联合实验室,开封475004 3河南大学淮河医院心内科,开封475000 4心内科,开封475000复旦大学附属华山医院,上海200040*通讯:钟晓明(zxm10020202@126.com);摘要:急性心肌梗死(AMI)与重度抑郁障碍(MDD)之间的密切关联已被普遍接受。AMI合并重度抑郁症的患者往往预后较差。大多数早期的研究都集中在AMI如何导致重度抑郁症上,但关于抑郁症引起的AMI的报道很少。从机制上看,炎症、下丘脑-垂体-肾上腺轴(HPA轴)和脑肠轴可能参与AMI后MDD的发生发展。MDD患者的炎症损伤、交感和迷走神经活动异常、HPA轴过度激活、暴饮暴食和一些治疗性药物的使用也可能是AMI的危险因素。行为和药物干预对AMI合并重度抑郁症的治疗都很重要。更多的药物正在开发和测试中。目前,AMI合并MDD的诊断、发病机制、干预策略和治疗药物等方面仍有许多问题需要解决。为了帮助临床诊断和治疗,本文对AMI合并MDD的现有研究进行了分类,并包括了我们的一些考虑。
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Pathophysiological Mechanisms and Pharmaceutical Interventions of Myocardial Infarction with Depression
Review Pathophysiological Mechanisms and Pharmaceutical Interventions of Myocardial Infarction with Depression Mingyang Xu 1, Yinxiang Wei 2, Zhenhui Wang 1, Yaohui Wang 2, Xiaoming Zhong 3,*, and Qiying Chen 4,* 1 School of medicine, Henan University, Kaifeng 475000, China. 2 Joint National Laboratory for Antibody Drug Engineering, Henan University, Kaifeng 475004, China. 3 Department of Cardiology, Huaihe Hospital of Henan University, Kaifeng 475000, China. 4 Department of Cardiology, Huashan Hospital, Fudan University, Shanghai 200040, China. * Correspondence: Xiaoming Zhong (zxm10020202@126.com); Qiying Chen (chenqiying@huashan.org.cn)     Received: 23 March 2023 Accepted: 10 May 2023   Abstract: The strong association between acute myocardial infarction (AMI) and major depression disorder(MDD)is a universally accepted. Patients with AMI complicated by MDD often have poor prognosis. Most early studies focused on how AMI leads to MDD, but there are few reports on depression-induced AMI. In terms of mechanism, inflammation, the hypothalamic-pituitary-adrenal axis (HPA axis) and brain-gut axis may be involved in the occurrence and development of MDD after AMI. The inflammatory injury, abnormal sympathetic and vagal nerve activity, HPA axis overactivation, overeating and some therapeutic medicine administration in patients with MDD can also be risk factors for AMI. Both behavioral and pharmaceutical interventions are important for the treatment of AMI with MDD. More drugs are being developed and tested. At present, there are still many issues, needing to be addressed, in the diagnosis, pathogenesis, intervention strategies and therapeutic drugs for AMI with MDD. To aid clinical diagnosis and treatment, this review classifies the existing studies on AMI complicated with MDD, and also includes some of our considerations.
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