巧克力消费(可可可可L.)对高血压患者血胆固醇和甘油三酯水平的影响在Jatiroto健康中心,印度尼西亚

Muzaroah Ermawati Ulkhasanah, S. Hadisaputro, Rr. Sri Endang Pujiastuti
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引用次数: 0

摘要

背景:高血压受生活方式因素的影响,如高脂肪摄入,有可能导致高血胆固醇水平。可可制品富含类黄酮,已被证明可以降低血压和心血管疾病的风险。目的:本研究的目的是检查黑巧克力消费在降低高血压患者血液中胆固醇和甘油三酯的水平。方法:本研究采用准实验法,采用前后对照设计。采用随机抽样方法,于2018年6 - 7月在Jatiroto卫生中心抽取32例高血压患者。然后,受访者被分为(1)对照组,患者服用流行的非药物治疗辛伐他汀;(2)干预组,受访者服用辛伐他汀,并接受额外的黑巧克力60克/天(每天两次,每次30克),持续15天。采用546 nm波长甘油磷酸氧化酶(GPO-POD)分光光度计测定血胆固醇和甘油三酯水平。检验前后、对照组与干预组的差异均采用统计学分析t检验。结果:本研究承认单处方辛伐他汀对降低高血压患者的胆固醇水平有显著贡献(p值= 0.041),而仿制药辛伐他汀对降低高血压患者的甘油三酯水平没有显著作用(p值= 0.361)。在服用辛伐他汀处方的同时服用60克黑巧克力,可显著降低高血压患者的胆固醇和甘油三酯水平,分别达到57.06 mg/dL和38.41 mg/dL, p值= 0.001。在辛伐他汀处方中加入黑巧克力会显著降低血胆固醇水平(p值= 0.020),但对降低甘油三酯没有真正有效(p值= 0.560)。结论:研究结果表明,服用辛伐他汀处方的高血压患者给予黑巧克力比单独服用辛伐他汀药物更能降低胆固醇和甘油三酯水平。关键词:黑巧克力,辛伐他汀,高血压,胆固醇,甘油三酯
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The effect of chocolate consumption (Theobroma cacao L.) on level of blood cholesterol and triglyceride in hypertension patients at Jatiroto Health Center, Indonesia
Background: Hypertension is influenced by lifestyle factors such as high fat intake which has the potential for high blood cholesterol level. Cocoa products, which are rich sources of flavonoids, have been shown to reduce blood pressure and the risk of cardiovascular disease.Aims: The purpose of this research is to examine the dark chocolate consumption in decreasing the level of blood cholesterol and triglyceride in hypertension patients.Methods: This research is a quasi-experiment study with pre and post and control group design. There were thirty two (32) hypertensive patients selected from Jatiroto Health Center in June-July 2018 using a random sampling technique. The respondents were then divided to (1) a control group where patients were prescribed to a popular non-pharmacological therapy Simvastatin and (2) an intervention group where the respondents were prescribed with Simvastatin and also received an additional dark chocolate 60gr/day (given twice a day, each 30gr) for 15 days. A spectrophotometer glycerol phosphate oxidase (GPO-POD) with 546 nm wavelength was employed to measure the levels of blood cholesterol and triglyceride. The significant mean difference between pre and posttest, and the changes between control and intervention group were defined by statistical analysis T-test.Results: This study acknowledged that the prescribed simvastatin alone presents a significant contribution to decrease the cholesterol level at 14.40 point (p value = 0.041), however, the generic is not enough to deliver a significant effect to the decrease of triglyceride level in the hypertension patients (p value = 0.361). A great contribution to the depression of cholesterol and triglyceride level in the hypertensive respondent was observed if simvastatin prescription was combined with a provision of 60 gram dark chocolate, respectively to the level of 57.06 and 38.41 mg/dL with p value = 0.001. The addition of dark chocolate in the simvastatin prescription will significantly reduce the blood cholesterol level (p value = 0.020), but not really effective to reduce the triglyceride (p value = 0.560).Conclusion: The findings suggest that giving dark chocolate to the hypertensive patients who receive simvastatin prescription will decrease the cholesterol and triglyceride levels greater than the consumption of simvastatin drugs alone. Keywords: Dark chocolate, Simvastatin, Hypertension, Cholesterol, Triglyceride
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