金属蛋白酶之间的历史,健康,疾病,和健康的社会决定因素的复杂维度

David Costa, Nicola Ielapi, R. Minici, E. Bevacqua, S. Ciranni, L. Cristodoro, G. Torcia, M. D. Di Taranto, U. Bracale, M. Andreucci, R. Serra
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引用次数: 0

摘要

金属蛋白酶(MPs)属于锌内肽酶超家族,被称为锌内肽酶。在人类健康和患病条件下研究了三个MPs家族。关于MPs的第一项研究发表于1962年,此后,几项研究描述了它们的活性及其对健康和疾病的影响。许多疾病都与MPs有关,如心血管疾病、癌症、炎症性疾病、妇科疾病等。此外,金属蛋白酶的组织抑制剂(TIMPs)已经得到了广泛的研究,并且已经对靶向MP活性的药物和人工分子进行了评估。MPs与公共卫生相关,因为它们在几种疾病中发挥作用,最重要的是,它们作为生物标志物的作用也影响受影响患者的生活质量和心理社会层面。在这种情况下,在MPs领域开辟了精确健康和精确医学的新途径。本综述从最初的研究出发,描述了MPs的复杂维度以及以健康和疾病维度为中心的相关问题。
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Metalloproteinases between History, Health, Disease, and the Complex Dimension of Social Determinants of Health
Metalloproteinases (MPs) belong to the superfamily of zinc endopeptidases, which are called metzincins. Three families of MPs have been studied in healthy and diseased conditions in humans. The first study on MPs was published in 1962, and following that, several studies characterized their activity and their effect on health and disease. Several diseases have been related to MPs, such as cardiovascular disease, cancer, inflammatory diseases, gynecological disorders, and others. Moreover, tissue inhibitors of metalloproteinases (TIMPs) have been widely studied, and drugs and artificial molecules that could target MP activity have been evaluated. MPs are relevant to public health because of their role in several diseases and, most of all, their role as biomarkers that also impact the quality of life and the psychosocial dimension of affected patients. In this context, new pathways to precision health and precision medicine have been opened in the area of MPs. This review describes, from the initial studies, the complex dimensions of MPs and related issues centered on health and disease dimensions.
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