接触油漆稀释剂中使用的甲苯的职业工人I期代谢基因多态性与姐妹染色单体交换的关系

Q3 Biochemistry, Genetics and Molecular Biology Genetics Research International Pub Date : 2015-11-24 DOI:10.1155/2015/630296

K. Priya, A. Yadav, Neeraj Kumar, Sachin Gulati, N. Aggarwal, Ranjan Gupta

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引用次数: 5

摘要

本研究调查了主要暴露于甲苯的油漆工人的遗传损伤，因为甲苯是油漆稀释剂中使用的主要溶剂。采用姐妹染色单体交换(SCE)试验作为遗传毒性的生物标志物。采集了30名油漆工人和30名对照对象的血液样本，这些样本在年龄和其他混杂因素方面相匹配，除了接触甲苯。油漆工人的SCE频率(4.81±0.92)明显高于对照组(1.73±0.54)(p < 0.05)。我们还研究了CYP2E1和CYP1A1m2基因多态性对SCE频率的影响。我们的研究结果表明，与野生基因型相比，CYP2E1和CYP1A1m2突变基因型的SCE频率显著增加。我们的研究表明，长期接触甲苯会增加油漆工人的遗传毒性风险。

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Association of Polymorphisms of Phase I Metabolizing Genes with Sister Chromatid Exchanges in Occupational Workers Exposed to Toluene Used in Paint Thinners

This study investigated genetic damage in paint workers mainly exposed to toluene as it is a major solvent used in paint thinners. Sister chromatid exchange (SCE) assay was used as biomarker of genotoxicity. Blood samples were collected from 30 paint workers and 30 control subjects matched with respect to age and other confounding factors except for exposure to toluene. SCE frequency was found to be significantly higher in paint workers (4.81 ± 0.92) as compared to control individuals (1.73 ± 0.54) (p < 0.05). We also investigated influence of polymorphisms of CYP2E1 and CYP1A1m2 genes on SCE frequency. Our results showed that there was significant increase in frequencies of SCE among the mutant genotypes of CYP2E1 and CYP1A1m2 as compared to wild genotypes. Our study indicated that long term exposure of toluene can increase genotoxic risk in paint workers.

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来源期刊

Genetics Research International Biochemistry, Genetics and Molecular Biology-Genetics

CiteScore

2.90

自引率

0.00%

发文量

期刊介绍： Genetics Research International is a peer-reviewed, Open Access journal that publishes original research articles as well as review articles in all areas of genetics and genomics. The journal focuses on articles bearing on heredity, biochemistry, and molecular biology, as well as clinical findings.