左心室原始状态及冠状动脉搭桥术技术特点对移植物功能安全性的影响

N. S. Lisyutenko, N. Morova, V. N. Tsekhanovich
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引用次数: 0

摘要

本研究的目的是研究左心室心肌初始状态以及冠状动脉旁路移植术(CABG)的技术特点对冠状动脉分流功能预后的影响。材料和方法。对46例因稳定性III级心绞痛行冠脉搭桥的患者进行了研究。2型糖尿病(DM2) 23例,无碳水化合物代谢障碍23例。手术前夜,所有患者均行经胸超声心动图检查左心室功能指标。关于冠脉搭桥技术特征的信息来源于手术报告。手术一年后,所有患者都进行了冠状动脉和搭桥血管造影。有DM2的10例患者有冠状动脉分流闭塞,无DM2的6例患者有冠状动脉分流闭塞(Fisher精确检验的p值为0.177)。左心室舒张末期和收缩末期直径增大(Mann-Whitney检验的p值为0.004;0.012),以及更大的左心室舒张末期和收缩末期容积(Mann-Whitney试验的p值为0.012;0.006)与DM2患者存在冠状动脉分流闭塞相关。同样,在DM2患者组中,顺序静脉分流阻塞的频率明显更高(Fisher精确检验的p值为0.004)。在没有碳水化合物代谢紊乱的患者中,分流功能障碍与上述数字相关。本研究结果证实了危险因素对冠脉搭桥术后预后的相互影响
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INFLUENCE OF THE ORIGINAL STATE OF THE LEFT VENTRICLE AND TECHNICAL FEATURES OF CORONARY ARTERY BYPASS SURGERY ON THE FUNCTIONAL SAFETY OF GRAFTS
The goal of research is to study the influence of the initial state of left ventricular myocardium, as well as the technical features of the coronary artery bypass graft (CABG) on the prognosis of the functioning of coronary shunts.Materials and methods. 46 men, who had CABG for stable angina class III, were examined. 23 of them had 2 type diabetes mellitus (DM2), 23 of them did not have carbohydrate metabolism disorders. On the eve of the surgery, all patients underwent transthoracic echocardiography to determine the indicators of left ventricular function. Information about the technical features of the CABG were taken from the surgical reports. One year after the surgery, all patients underwent a coronary and bypass angiography.Results. Occlusion of coronary shunts was detected in 10 patients with DM2, and in 6 patients without DM2 (p value for Fisher’s exact test is 0.177). A larger left ventricle end-diastolic and end-systolic diameter (p value for the Mann-Whitney test is 0.004; 0.012), as well as a larger left ventricle end-diastolic and end-systolic volume (p value for the Mann-Whitney test is 0.012; 0.006) were associated with the presence of coronary shunt occlusions in patients with DM2. Also in the group of patients with DM2, sequential venous shunts were significantly more frequently occluded (p value for Fisher’s exact test is 0.004). Dysfunctioning shunts were associated with abovementioned figures among patients without carbohydrate metabolism disorders.Conclusion. The results of the research confirm the mutual confounding influence of risk factors on the prognosis after CABG
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