{"title":"知道何时进行分支","authors":"","doi":"10.1126/scisignal.2042003tw406","DOIUrl":null,"url":null,"abstract":"Neuronal axons form branches to establish precise connections with their targets, but branch control is not well understood. Colavita and Tessier-Lavigne have identified a subset of neurons in Caenorhabditis elegans that require a membrane protein called BAM-2 (branching abnormal) to stop formation of branches and to stabilize their termination. Loss of BAM-2 allowed branches to overshoot their normal termination sites. BAM-2 shows sequence similarity to neurexins that are thought to control the stability of neuronal synapses. A. Colavita, M. Tessier-Lavigne, A neurexin-related protein, BAM-2, terminates axonal branches in C. elegans. Science 302, 293 (2003). [Abstract] [Full Text]","PeriodicalId":21619,"journal":{"name":"Science's STKE","volume":"2015 1","pages":"TW406 - tw406"},"PeriodicalIF":0.0000,"publicationDate":"2003-10-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Knowing When to Branch\",\"authors\":\"\",\"doi\":\"10.1126/scisignal.2042003tw406\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"Neuronal axons form branches to establish precise connections with their targets, but branch control is not well understood. Colavita and Tessier-Lavigne have identified a subset of neurons in Caenorhabditis elegans that require a membrane protein called BAM-2 (branching abnormal) to stop formation of branches and to stabilize their termination. Loss of BAM-2 allowed branches to overshoot their normal termination sites. BAM-2 shows sequence similarity to neurexins that are thought to control the stability of neuronal synapses. A. Colavita, M. Tessier-Lavigne, A neurexin-related protein, BAM-2, terminates axonal branches in C. elegans. Science 302, 293 (2003). [Abstract] [Full Text]\",\"PeriodicalId\":21619,\"journal\":{\"name\":\"Science's STKE\",\"volume\":\"2015 1\",\"pages\":\"TW406 - tw406\"},\"PeriodicalIF\":0.0000,\"publicationDate\":\"2003-10-14\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Science's STKE\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://doi.org/10.1126/scisignal.2042003tw406\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"\",\"JCRName\":\"\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Science's STKE","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.1126/scisignal.2042003tw406","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
引用次数: 0
摘要
神经元轴突形成分支以与它们的目标建立精确的连接，但分支控制尚不清楚。Colavita和Tessier-Lavigne已经在秀丽隐杆线虫中发现了一个神经元子集，它需要一种叫做BAM-2(分支异常)的膜蛋白来阻止分支的形成并稳定它们的终止。bam2的缺失使得分支超过了它们正常的终止位点。bam2的序列与被认为控制神经元突触稳定性的神经素相似。A. Colavita, M. Tessier-Lavigne，神经素相关蛋白bam2在线虫轴突分支终止中的作用。科学302,293(2003)。【摘要】【全文】
Neuronal axons form branches to establish precise connections with their targets, but branch control is not well understood. Colavita and Tessier-Lavigne have identified a subset of neurons in Caenorhabditis elegans that require a membrane protein called BAM-2 (branching abnormal) to stop formation of branches and to stabilize their termination. Loss of BAM-2 allowed branches to overshoot their normal termination sites. BAM-2 shows sequence similarity to neurexins that are thought to control the stability of neuronal synapses. A. Colavita, M. Tessier-Lavigne, A neurexin-related protein, BAM-2, terminates axonal branches in C. elegans. Science 302, 293 (2003). [Abstract] [Full Text]
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