母体脂质可预测2型糖尿病和妊娠期糖尿病孕妇的胎儿生长

Prilozi Pub Date : 2016-11-01 DOI:10.1515/prilozi-2016-0022
B. Krstevska, S. Jovanovska, Slagjana Simeonova Krstevska, V. V. Nakova, V. Serafimoski
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引用次数: 7

摘要

目的:糖尿病妊娠期间,脂质谱发生复杂的代谢变化。本研究的目的是确定2型糖尿病(DM2)和妊娠期糖尿病(GDM)孕妇妊娠晚期大胎龄新生儿的母亲血清脂质水平的预测价值。资料与方法:对43例妊娠期DM2妇女和200例妊娠期GDM妇女的资料进行分析。分析包括以下参数:年龄、体重指数(BMI)、脂质参数、妊娠前、中、晚期HbA1c、先兆子痫和婴儿出生体重。结果:DM2 GDM组显示,在统计上有显著差异的以下变量:总脂质、甘油三酯、总胆固醇、体重指数、年龄、婴儿出生体重,SGA发生率和早产(9.4±2.3和11.0±2.3更易/ L, 2.4±1.4和3.4±1.6更易/ L, 5.5±1.2和6.4±1.4更易/ L, 30.6±5.4和26.9±5.2 kg / m2, 34±7.8和31.5±5.6年,3183±972和3533±699克,20%比7.5%、27.9和14%,分别为p < 0.05)。线性多元回归分析显示,甘油三酯、LDL-C和总胆固醇是LGA的独立预测因子(p < 0.05)。结论:妊娠晚期甘油三酯和LDL-C是DM2和GDM妊娠胎儿巨大儿的独立预测因子。因此,在妊娠晚期采集的母体血液中测定的血清甘油三酯和LDL-C水平可以确定分娩LGA新生儿的妇女。
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Maternal Lipids May Predict Fetal Growth in Type 2 Diabetes Mellitus and Gestational Diabetes Mellitus Pregnancies
Abstract Aim: During diabetic pregnancy, complex metabolic changes occur in the lipid profile. The aim of the study was to determine the predictive values of maternal serum lipid levels on large-for-gestational age newborns during the third trimester in pregnancies of women with type 2 diabetes mellitus (DM2) and gestational diabetes mellitus (GDM). Material and methods: Data of forty three pregnancies of women with DM2 and two hundred women with GDM were analyzed. The analysis encompassed the following parameters: age, body mass index (BMI), lipid parameters, HbA1c in first, second and third trimester of pregnancy, preeclampsia and baby birth weight. Results: DM2 and GDM groups showed statistically significant differences in the following variables: total lipids, triglycerides, total cholesterol, BMI, age, baby birth weight, incidence of SGA and preterm delivery (9.4 ± 2.3 vs. 11.0 ± 2.3 mmol/L, 2.4 ± 1.4 vs. 3.4 ± 1.6 mmol/L, 5.5 ± 1.2 vs. 6.4 ± 1.4 mmol/L, 30.6 ± 5.4 vs. 26.9 ± 5.2 kg/m2, 34 ± 7.8 vs. 31.5 ± 5.6 years, 3183 ± 972 vs. 3533 ± 699 g., 20% vs. 7.5%, 27.9 vs. 14%, respectively, p < 0.05). Linear multiple regression analysis demonstrated that triglycerides, LDL-C and total cholesterol were independent predictors of LGA (p < 0.05). Conclusion: Triglycerides and LDL-C in the third trimester of pregnancy are independent predictors for fetal macrosomia in DM2 and GDM pregnancies. Thus, the maternal serum triglycerides and LDL-C levels determined in the maternal blood taken in the third trimester of pregnancy may indentify women who will give birth to LGA newborns.
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