给结肠输送潜在药物:挑战和策略

IF 0.7 Q4 PHARMACOLOGY & PHARMACY INDONESIAN JOURNAL OF PHARMACY Pub Date : 2022-04-22 DOI:10.22146/ijp.2734
R. Iswandana, K. Putri, Sekar Arum Larasati, Maxius Gunawan, Fathia Amalia Putri
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引用次数: 2

摘要

结肠靶向药物递送系统已被用于治疗结肠局部疾病、蛋白质和肽的全身递送以及时间治疗药物。上胃肠道限制了这些药物的有效递送。因此,需要几种策略来直接靶向结肠药物,如ph敏感聚合物、酶敏感聚合物、细菌可降解多糖、时间依赖性聚合物和颗粒系统。然而,个体胃肠道的可变生理条件导致这些策略的组合需要确保药物的结肠递送。本文介绍并讨论了几种潜在的药物及其用于设计和开发具有特定特征的结肠靶向给药系统的方法。
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Delivery of Potential Drugs to The Colon: Challenges and Strategies
Colon-targeted drug delivery systems have been exploited to treat local diseases in the colon, systemic delivery of protein and peptide, and chronotherapeutic drugs. The upper gastrointestinal tract restricts the effective delivery of these drugs. Therefore, several strategies are needed for targeted drugs directly to the colon, such as pH-sensitive polymers, enzyme-sensitive polymers, bacterially degradable polysaccharides, time-dependent polymers, and particulate systems. However, variable physiological conditions of the gastrointestinal tract in individuals cause combinations of these strategies are needed to ensure colonic delivery of the drug. This review presents and discusses several potential drugs and their approaches used to design and develop colon-targeted drug delivery systems for medications with particular characteristics.
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来源期刊
INDONESIAN JOURNAL OF PHARMACY
INDONESIAN JOURNAL OF PHARMACY PHARMACOLOGY & PHARMACY-
CiteScore
1.20
自引率
0.00%
发文量
38
审稿时长
12 weeks
期刊介绍: The journal had been established in 1972, and online publication was begun in 2008. Since 2012, the journal has been published in English by Faculty of Pharmacy Universitas Gadjah Mada (UGM) Yogyakarta Indonesia in collaboration with IAI (Ikatan Apoteker Indonesia or Indonesian Pharmacist Association) and only receives manuscripts in English. Indonesian Journal of Pharmacy is Accredited by Directorate General of Higher Education. The journal includes various fields of pharmaceuticals sciences such as: -Pharmacology and Toxicology -Pharmacokinetics -Community and Clinical Pharmacy -Pharmaceutical Chemistry -Pharmaceutical Biology -Pharmaceutics -Pharmaceutical Technology -Biopharmaceutics -Pharmaceutical Microbiology and Biotechnology -Alternative medicines.
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