WNT信号通路的形态发生蛋白在冠状动脉疾病中的作用

I. Snimshchikova, M. Plotnikova
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引用次数: 0

摘要

近年来,研究人员将注意力转向了调控胚胎发生过程并参与病理状态发展的WNT信号通路的研究。WNT信号通路的形态发生蛋白在心血管病理发生中的作用目前尚不清楚。本研究旨在全面研究2019 - 2021年在Orel地区血管中心接受治疗的353例急性冠状动脉疾病患者血清中WNT信号通路主要蛋白(β-catenin、sclerostin、GSK-3α、GSK-3β、wi -1和DVL-1)的表达情况。综合分析包括当前临床指南框架下的临床、实验室和仪器参数评估,以及通过酶免疫分析法确定WNT信号的形态发生蛋白的免疫学检查。结果显示,患者血清中WNT信号通路的形态发生蛋白值存在广泛的差异。β-catenin、WIF-1和DVL-1的水平显著高于健康个体,而硬化蛋白和GSK-3β的浓度与健康个体无显著差异。患者GSK-3α水平较健康人群低2倍。在主动脉瓣小叶和主动脉壁存在钙化的患者中发现最高的硬化蛋白浓度。在极高和极低的患者中均观察到急性冠状动脉综合征的不良病程。WNT信号通路形态发生蛋白水平与脂质代谢及心肌重构呈显著相关。获得的WNT信号通路蛋白产生变化的数据使我们扩大了对冠状动脉疾病心肌重构免疫发病机制的分子方面的认识,增加了心血管疾病诊断的预测潜力,并为进一步发展心脏免疫学测定确定了载体。
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Role of morphogenic proteins of the WNT signaling pathway in coronary artery disease
In recent years, researchers’ attention has been directed to the WNT signaling pathway study, which regulates embryogenesis processes and is involved in pathological condition development. The role of morphogenic proteins of WNT signaling pathway in the cardiovascular pathology genesis is practically not clear. The research aim was a comprehensive study of the main proteins of WNT signaling pathway (β-catenin, sclerostin, GSK-3α, GSK-3β, WIF-1 and DVL-1) in the blood serum of 353 patients with coronary artery disease acute forms who were treated at the Orel regional vascular center from 2019 to 2021, and 50 healthy individuals. A comprehensive analysis included an assessment of clinical, laboratory and instrumental parameters in the framework of current clinical guidelines, as well as an immunological examination to determine the morphogenic proteins of WNT signaling by enzyme immunoassay. The results showed a wide variability in the values of morphogenic proteins of WNT signaling pathway in the patient’s blood serum. The levels of β-catenin, WIF-1 and DVL-1 significantly exceeded those obtained in healthy individuals, while the concentrations of sclerostin and GSK-3β did not differ significantly from them. The level of GSK-3α of patients was twice lower than in healthy individuals. The highest sclerostin concentrations were found in patients with existing calcification of the aortic valve leaflets and aortic walls. Acute coronary syndrome unfavorable course was observed in patients with both extremely high and extremely low WIF-1 levels. Significant correlations were established between the level of morphogenic proteins of WNT signaling pathway and lipid metabolism, as well as myocardial remodeling. The obtained data on changes in the protein production of WNT signaling pathway allow us to expand our understanding of the molecular aspects of the immunopathogenesis of myocardial remodeling in coronary artery disease, increase the predictive potential for cardiovascular disease diagnosis and determine the vector for further development of cardioimmunology determination.
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来源期刊
Medical Immunology (Russia)
Medical Immunology (Russia) Medicine-Immunology and Allergy
CiteScore
0.70
自引率
0.00%
发文量
88
审稿时长
12 weeks
期刊介绍: The journal mission is to promote scientific achievements in fundamental and applied immunology to various medical fields, the publication of reviews, lectures, essays by leading domestic and foreign experts in the field of fundamental and experimental immunology, clinical immunology, allergology, immunodiagnostics and immunotherapy of infectious, allergy, autoimmune diseases and cancer.
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