{"title":"阿终不同部位大鼠降胆固醇活性的研究","authors":"H. P. Shaila, S. Udupa, A. Udupa","doi":"10.1211/146080800128736141","DOIUrl":null,"url":null,"abstract":"The hypocholesterolaemic activity of different fractions from Terminalia arjuna were tested on rats fed an atherogenic diet. In the control group the feeding of cholesterol led to a 97% increase in serum cholesterol levels at the end of three weeks. The alcoholic and aqueous fractions inhibited this rise in serum cholesterol. The faecal excretion of total bile acids in rats fed with these fractions was increased. The possible mechanism of action of the cholesterol-reducing activity of these fractions may be due to the rapid excretion of bile acids.","PeriodicalId":19946,"journal":{"name":"Pharmacy and Pharmacology Communications","volume":null,"pages":null},"PeriodicalIF":0.0000,"publicationDate":"2000-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"1","resultStr":"{\"title\":\"Hypocholesterolaemic Activity in Rats of Different Fractions from Terminalia arjuna\",\"authors\":\"H. P. Shaila, S. Udupa, A. Udupa\",\"doi\":\"10.1211/146080800128736141\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"The hypocholesterolaemic activity of different fractions from Terminalia arjuna were tested on rats fed an atherogenic diet. In the control group the feeding of cholesterol led to a 97% increase in serum cholesterol levels at the end of three weeks. The alcoholic and aqueous fractions inhibited this rise in serum cholesterol. The faecal excretion of total bile acids in rats fed with these fractions was increased. The possible mechanism of action of the cholesterol-reducing activity of these fractions may be due to the rapid excretion of bile acids.\",\"PeriodicalId\":19946,\"journal\":{\"name\":\"Pharmacy and Pharmacology Communications\",\"volume\":null,\"pages\":null},\"PeriodicalIF\":0.0000,\"publicationDate\":\"2000-07-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"1\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Pharmacy and Pharmacology Communications\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://doi.org/10.1211/146080800128736141\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"\",\"JCRName\":\"\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Pharmacy and Pharmacology Communications","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.1211/146080800128736141","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
Hypocholesterolaemic Activity in Rats of Different Fractions from Terminalia arjuna
The hypocholesterolaemic activity of different fractions from Terminalia arjuna were tested on rats fed an atherogenic diet. In the control group the feeding of cholesterol led to a 97% increase in serum cholesterol levels at the end of three weeks. The alcoholic and aqueous fractions inhibited this rise in serum cholesterol. The faecal excretion of total bile acids in rats fed with these fractions was increased. The possible mechanism of action of the cholesterol-reducing activity of these fractions may be due to the rapid excretion of bile acids.
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