{"title":"PEMBUATAN MIKROKRISTALIN SELULOSA (MCC) dari BATANG PISANG MAS (Musa acuminata colla) dengan AVICEL PH 102 SEBAGAI PEMBANDING TAHUN 2019","authors":"Erdiwan Erdiwan","doi":"10.36656/jpfh.v4i2.866","DOIUrl":null,"url":null,"abstract":"Commercial cellulose microcrystalline known as Avicel PH 102, which is a tablet filling material Avicel PH 102 which is expensive and uses a lot of it, it is necessary to look for other alternative sources of producing microcrystalline cellulose. The Waste of banana stem contains water content of 80-90%, cellulose 63-64%, hemicellulose 20%, and lignin 5% and contains 11-12% other constituens so that it can be the basic material for making MCC. This study aimed to isolate α-cellulose from banana mas stems and characterize microcrystalline cellulose with Avicel PH 102. The method of this study was an experimental. Microcrystalline banana stem cellulose is obtained by heating banana stem powder with 4% NaOH which serves to dissolve lignin, then bleached with 2.5% NaOCl, 17.5% NaOH heated to dissolve β-cellulose and γ-cellulose, and heated with HCL 2 N . The results are hydrolyzed with α-cellulose and then hydrolyzed with 2.5N HCl to give microcrystalline cellulose, which is characterized and compared to Avicel PH102. The result of characterization of banana mas stem microcrystalline cellulose and Avicel PH 102 which were obtained respectively is organoleptic tests of coarse powder, white, doesn’t have any smells; pH 6.6 and 6.5; solubility of substances in water 0.023 and 0.023%; total ash content are 0.17 and 0.12%; decrease of drying 5.47 and 5.28%; real density 0.337 and 0.404 g / cm3; true type weight 1.43 and 1.43 g / cm3; incompressible density 0.478 and 0.480 g / cm3; compressibility index 41.77 and 18.85%; Hausner index 1.41 and 1.18; porosity; 76.43 and 93.640%. Based on the results of the study concluded that microcrystalline cellulose can be made from banana mas stems and has the same characteristics as Avicel PH 102.","PeriodicalId":17717,"journal":{"name":"Jurnal Penelitian Farmasi & Herbal","volume":"11 1","pages":""},"PeriodicalIF":0.0000,"publicationDate":"2022-04-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Jurnal Penelitian Farmasi & Herbal","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.36656/jpfh.v4i2.866","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
引用次数: 0
摘要
商用纤维素微晶称为Avicel PH 102,这是一种片剂填充材料,Avicel PH 102价格昂贵且用量很大,有必要寻找其他替代来源生产微晶纤维素。香蕉茎废弃物的含水量为80-90%,纤维素含量为63-64%,半纤维素含量为20%,木质素含量为5%,其他成分含量为11-12%,可作为制备MCC的基础原料。本研究旨在从香蕉茎中分离α-纤维素,并用Avicel PH 102对微晶纤维素进行表征。这项研究的方法是实验性的。用4%的NaOH溶解木质素,将香蕉茎粉加热,2.5% NaOCl漂白,17.5% NaOH加热溶解β-纤维素和γ-纤维素,HCL 2 N加热,得到微晶香蕉茎纤维素。结果经α-纤维素水解,再经2.5N HCl水解得到微晶纤维素,并与Avicel PH102进行了表征和比较。对香蕉茎微晶纤维素和Avicel PH 102分别进行了感官测试,结果为粗粉,白色,无任何气味;pH 6.6和6.5;物质在水中的溶解度0.023和0.023%;总灰分分别为0.17和0.12%;干燥降低5.47%和5.28%;实密度0.337、0.404 g / cm3;真型重量1.43和1.43 g / cm3;不可压缩密度0.478和0.480 g / cm3;压缩指数分别为41.77和18.85%;Hausner指数分别为1.41和1.18;孔隙度;76.43和93.640%。研究结果表明,以香蕉茎为原料制备的微晶纤维素具有与Avicel PH 102相同的特性。
PEMBUATAN MIKROKRISTALIN SELULOSA (MCC) dari BATANG PISANG MAS (Musa acuminata colla) dengan AVICEL PH 102 SEBAGAI PEMBANDING TAHUN 2019
Commercial cellulose microcrystalline known as Avicel PH 102, which is a tablet filling material Avicel PH 102 which is expensive and uses a lot of it, it is necessary to look for other alternative sources of producing microcrystalline cellulose. The Waste of banana stem contains water content of 80-90%, cellulose 63-64%, hemicellulose 20%, and lignin 5% and contains 11-12% other constituens so that it can be the basic material for making MCC. This study aimed to isolate α-cellulose from banana mas stems and characterize microcrystalline cellulose with Avicel PH 102. The method of this study was an experimental. Microcrystalline banana stem cellulose is obtained by heating banana stem powder with 4% NaOH which serves to dissolve lignin, then bleached with 2.5% NaOCl, 17.5% NaOH heated to dissolve β-cellulose and γ-cellulose, and heated with HCL 2 N . The results are hydrolyzed with α-cellulose and then hydrolyzed with 2.5N HCl to give microcrystalline cellulose, which is characterized and compared to Avicel PH102. The result of characterization of banana mas stem microcrystalline cellulose and Avicel PH 102 which were obtained respectively is organoleptic tests of coarse powder, white, doesn’t have any smells; pH 6.6 and 6.5; solubility of substances in water 0.023 and 0.023%; total ash content are 0.17 and 0.12%; decrease of drying 5.47 and 5.28%; real density 0.337 and 0.404 g / cm3; true type weight 1.43 and 1.43 g / cm3; incompressible density 0.478 and 0.480 g / cm3; compressibility index 41.77 and 18.85%; Hausner index 1.41 and 1.18; porosity; 76.43 and 93.640%. Based on the results of the study concluded that microcrystalline cellulose can be made from banana mas stems and has the same characteristics as Avicel PH 102.