COVID-19患者甲状腺功能评估

A. Mohammed, A. Yousif, Samir Anwar Jabbar, P. Ismail
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引用次数: 2

摘要

自2019冠状病毒病(COVID-19)爆发以来,全球已有200多个国家和地区受到影响。目前尚不清楚COVID-19是否对甲状腺功能有影响。本研究的目的是评估有甲状腺病史和无甲状腺病史的COVID-19患者的甲状腺功能,并了解两组患者的甲状腺功能障碍。本研究涉及2021年1月至4月期间入住BioLab和伊拉克埃尔比勒Balsam医院的86名COVID-19感染患者。采用鼻咽拭子逆转录聚合酶链反应(RT-PCR)证实所有患者感染COVID-19。分析和评估甲状腺激素、促甲状腺素(TSH)水平。大多数参与者(88.4%)T3水平正常,T3、TPO正常、无甲状腺病史者与有甲状腺病史和/或高TPO者之间无显著差异(p = 0.069)。无甲状腺疾病史和TPO正常的受试者与有甲状腺疾病史和/或TPO高的受试者的T4水平无显著差异(p =0.725)。两组间TSH水平差异有统计学意义(p<0.001)。有甲状腺疾病家族史、TPO抗体水平较高的新冠肺炎患者亚临床甲状腺功能减退的发生率较高。
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Assessment of Thyroid Function in COVID-19 Patients
Since the egression of the coronavirus 2019 (COVID-19) disease, more than 200 countries and areas around the world were affected. To the present, it is not clear whether COVID-19 has effects on thyroid function or not. The aim of the current study was to assess thyroid function in COVID-19 patients with history of thyroid disease and those without such a history and to find out the thyroid disturbance in both groups. The present study involved 86 COVID-19 affected patients admitted BioLab and the Balsam Hospital, Erbil/ Iraq between January and April 2021. Confirmation of COVID-19 infection all patients by Reverse Transcriptase Polymerase Chain Reaction (RT-PCR) of nasopharyngeal swabs. Thyroid hormones, and thyrotropin (TSH) level was analyzed and assessed. Most of the participants (88.4%) had normal T3 level, and there was no significant difference (p = 0.069) between those with normal T3, TPO and with no history of thyroid disease and those with such a history and/or high TPO. T4 levels of the participants with no history of thyroid disease and normal TPO did not differ significantly (p =0.725) from those with a history of thyroid disease and/or high TPO. Regarding the level of TSH, there was significant difference (p<0.001) between the two fore mentioned groups. There is high prevalence of subclinical hypothyroidism in the COVID-19 patients with family history of thyroid disease and high TPO antibody level.
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