SESAME:用于生物测定的活性化合物分离的专家系统

Tetrahedron Computer Methodology Pub Date : 1989-01-01 DOI:10.1016/0898-5529(89)90029-8

Yves Francois Pouchus ∗, Abdel Fatah Benslimane, Jean-Francois Verbist

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引用次数: 3

摘要

对粗提物生物测定定向分馏结果进行数学分析，有助于有效成分的分离。根据不同馏分的质量和活度值，可以计算出与各馏分中活性化合物浓度增加有关的纯化指数，以及与各馏分中存在的活性化合物的量有关的相对回收率。SESAME就是一个基于这种方法的节目。它计算了对分馏解释有用的不同值，分析了活性化合物的纯化和保存效率，并给出了几种活性化合物可能存在的证据。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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SESAME: An expert system for bioassay-directed isolation of active compounds

Mathematical analysis of bioassay-directed fractionations results of crude extracts can help isolation of active compounds. From the values of weights and activities of the different fractions, it is possible to calculate purification indices related to the increase of concentration of the active compound in each fraction, and relative recovered quantities related to the amounts of active compound present in each fraction. SESAME is a program based on this method. It calculates the different values useful for the interpretation of a fractionation, and analyses the efficiency of the purification and the preservation of the active compound, and gives evidence of the possible presence of several active compounds.

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