红豆籽油的理化性质评价及其在药用皂制剂中的应用

J. Pandey, S. Acharya, Rakshya Bagale, Akriti Gupta, P. Chaudhary, Bikash Rokaya, Manju K.C., P. Aryal, Hari Prasad Devkota
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引用次数: 3

摘要

本研究的目的是评价从植物种子中提取的正己烷提取物红草籽油(PUSO)的碘值、酸值、皂化值、酯值、折射率、过氧化值、粘度等标准理化参数,并以提取油为基料制备酮康唑皂(2% w/w)。最终生产的酮康唑皂质量控制标准符合印度药典标准。用氢氧化钾(KOH)对PUSO进行碱性皂化处理,制得药用皂。酸值(21.78 mg KOH/g)、皂化值(194.13 mg KOH/g)、碘值(99.7 g I2/100 g)、酯值(172.35 mg KOH/g)、折射率(1.464)、粘度(192 centipoises [cps])等理化参数除过氧化值(19.23毫当量KOH/g)外,均符合工业标准。对药用皂的质量控制参数进行评价,其pH值(7.3)、泡沫形成能力(14.5 cm)、泡沫保持时间(15 min)、总脂肪含量(69.31%)、水分含量(10.35%)、药物含量(99.37%)等各项参数均在可接受范围内。总的来说,我们的研究表明,在制药和药妆工业中,竹属植物碱具有物理化学稳定性,适合以经济的方式生产化妆品、肥皂和洗发水,而不是使用昂贵的化学添加剂。此外,本研究表明,在治疗和商业上成功的酮康唑皂,具有所有所需的质量控制参数,可以用自然可用的油以低成本制造。
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Physicochemical evaluation of Prinsepia utilis seed oil (PUSO) and its utilization as a base in pharmaceutical soap formulation
This study aims to evaluate the standard physicochemical parameters, such as iodine value, acid value, saponification value, ester value, refractive index, peroxide value, and viscosity, of Prinsepia utilis (P. utilis) seed oil (PUSO) obtained as hexane extract from seeds, and to formulate ketoconazole soap (2% w/w) by using extracted oil as a base. The quality control standards of the final ketoconazole soap complied with the standards specified in Indian Pharmacopeia. Pharmaceutical soap was obtained by treating PUSO with potassium hydroxide (KOH), undergoing basic saponification. All physicochemical parameters, such as acid value (21.78 mg KOH/g), saponi-fication value (194.13 mg KOH/g), iodine value (99.7 g I2/100 g), ester value (172.35 mg KOH/g), refractive index (1.464), and viscosity (192 centipoises [cps]), conformed to industrial standards, except the peroxide value (19.23 milliequivalent KOH/g). Besides, evaluation of quality control parameters of pharmaceutical soap suggested that its various parameters, such as pH (7.3), foam-forming ability (14.5 cm), foam retention time (15 min), total fatty matter (69.31%), moisture content (10.35%), and drug content (99.37%), were within the acceptable limit. Overall, our study showed that P. utilis base was physicochemically stable and suitable for manufacturing cosmetic products, soaps, and shampoo in an economical manner, rather than using expensive chemical additives, in the pharmaceutical and cosmeceutical industry. Further, this study suggested that therapeutically and commercially successful ketoconazole soap, with all the required quality control parameters, could be manufactured by using naturally available oil at a low cost.
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