辐射与糖尿病视网膜病变:黑暗的协同作用

T. Gardiner, D. Archer, G. Silvestri, W. Amoaku
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引用次数: 0

摘要

多年来,临床报告和一些早期实验研究反映出,由于先前存在糖尿病而导致的放射性视网膜病变血管病理恶化已经被认识到。然而,放射性视网膜病变(RR)和糖尿病视网膜病变(DR)协同作用的潜在发病机制尚未被比较和评估,以了解这一现象。目前的工作引起了人们对活性氧(ROS)和活性氮(RNS)在辐射诱导的旁观者效应(RIBE)和衰老相关分泌表型(SASP)中作为持续细胞损伤条件和来源的常见介质的关注。糖尿病中慢性高血糖介导的氧化应激和抗氧化防御的缺失,以及DNA损伤感知和修复机制的受损,被认为是导致糖尿病患者RR严重程度增加的主要因素。我们的结论是,除了影响DNA损伤反应(DDR)的战略性基因突变外,糖尿病是放射治疗副作用中血管损伤的最重要的常见危险因素。
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Radiation and Diabetic Retinopathy: A Dark Synergy
Exacerbation of the vascular pathology in radiation retinopathy as a result of pre-existing diabetes has been recognized for many years, as reflected by clinical reports and a few early experimental studies. However, the underlying pathogenetic mechanisms for the synergistic interaction of radiation retinopathy (RR) and diabetic retinopathy (DR) have not been compared and evaluated for insight on this phenomenon. The present work draws attention to the roles of reactive oxygen species (ROS) and reactive nitrogen species (RNS) as common mediators of both conditions and sources of ongoing cellular injury in the radiation-induced bystander effect (RIBE) and the senescence-associated secretory phenotype (SASP). Chronic hyperglycemia-mediated oxidative stress and depleted antioxidant defense in diabetes, together with impaired DNA damage sensing and repair mechanisms, were identified as the primary elements contributing to the increased severity of RR in diabetic patients. We conclude that apart from strategic genetic mutations affecting the DNA damage response (DDR), diabetes represents the most significant common risk factor for vascular injury as a side effect of radiotherapy.
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来源期刊
Journal of International Translational Medicine
Journal of International Translational Medicine MEDICINE, RESEARCH & EXPERIMENTAL-
自引率
0.00%
发文量
317
审稿时长
8 weeks
期刊介绍: Journal of International Translational Medicine (JITM, ISSN 2227-6394), founded in 2012, is an English academic journal published by Journal of International Translational Medicine Co., Ltd and sponsored by International Fderation of Translational Medicine. JITM is an open access journal freely serving to submit, review, publish, read and download full text and quote. JITM is a quarterly publication with the first issue published in March, 2013, and all articles published in English are compiled and edited by professional graphic designers according to the international compiling and editing standard. All members of the JITM Editorial Board are the famous international specialists in the field of translational medicine who come from twenty different countries and areas such as USA, Britain, France, Germany and so on.
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